| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEJ71572.1 | adk | HMPREF0548_1592 | HMPREF0548_2064 | Guanylate kinase; COG: COG0194. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.885 |
| EEJ71572.1 | gmk | HMPREF0548_1592 | HMPREF0548_0828 | Guanylate kinase; COG: COG0194. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.953 |
| EEJ71572.1 | nrdD | HMPREF0548_1592 | HMPREF0548_1745 | Guanylate kinase; COG: COG0194. | Anaerobic ribonucleoside-triphosphate reductase; COG: COG1328. | 0.476 |
| EEJ71572.1 | nrdF | HMPREF0548_1592 | HMPREF0548_1585 | Guanylate kinase; COG: COG0194. | Ribonucleoside-diphosphate reductase, beta subunit; COG: COG0208. | 0.939 |
| EEJ71572.1 | nrdJ | HMPREF0548_1592 | HMPREF0548_1312 | Guanylate kinase; COG: COG0194. | Ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent. | 0.521 |
| EEJ71572.1 | pyk | HMPREF0548_1592 | HMPREF0548_1004 | Guanylate kinase; COG: COG0194. | Pyruvate kinase; COG: COG0469; Belongs to the pyruvate kinase family. | 0.957 |
| EEJ71572.1 | relA | HMPREF0548_1592 | HMPREF0548_0979 | Guanylate kinase; COG: COG0194. | RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.948 |
| EEJ71572.1 | tmk | HMPREF0548_1592 | HMPREF0548_2125 | Guanylate kinase; COG: COG0194. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.483 |
| adk | EEJ71572.1 | HMPREF0548_2064 | HMPREF0548_1592 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Guanylate kinase; COG: COG0194. | 0.885 |
| adk | cmk | HMPREF0548_2064 | HMPREF0548_1013 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Cytidylate kinase; COG: COG0283. | 0.707 |
| adk | gmk | HMPREF0548_2064 | HMPREF0548_0828 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.885 |
| adk | nrdD | HMPREF0548_2064 | HMPREF0548_1745 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Anaerobic ribonucleoside-triphosphate reductase; COG: COG1328. | 0.670 |
| adk | nrdF | HMPREF0548_2064 | HMPREF0548_1585 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Ribonucleoside-diphosphate reductase, beta subunit; COG: COG0208. | 0.948 |
| adk | nrdI | HMPREF0548_2064 | HMPREF0548_1586 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | nrdI protein; Belongs to the NrdI family. | 0.656 |
| adk | nrdJ | HMPREF0548_2064 | HMPREF0548_1312 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent. | 0.676 |
| adk | pyk | HMPREF0548_2064 | HMPREF0548_1004 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Pyruvate kinase; COG: COG0469; Belongs to the pyruvate kinase family. | 0.961 |
| adk | relA | HMPREF0548_2064 | HMPREF0548_0979 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | RelA/SpoT family protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. | 0.638 |
| adk | tmk | HMPREF0548_2064 | HMPREF0548_2125 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.755 |
| cmk | adk | HMPREF0548_1013 | HMPREF0548_2064 | Cytidylate kinase; COG: COG0283. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.707 |
| cmk | nrdD | HMPREF0548_1013 | HMPREF0548_1745 | Cytidylate kinase; COG: COG0283. | Anaerobic ribonucleoside-triphosphate reductase; COG: COG1328. | 0.599 |