| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEJ71178.1 | EEJ71572.1 | HMPREF0548_1910 | HMPREF0548_1592 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Guanylate kinase; COG: COG0194. | 0.470 |
| EEJ71178.1 | apt | HMPREF0548_1910 | HMPREF0548_0107 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.529 |
| EEJ71178.1 | gmk | HMPREF0548_1910 | HMPREF0548_0828 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.601 |
| EEJ71178.1 | guaA | HMPREF0548_1910 | HMPREF0548_1982 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.999 |
| EEJ71178.1 | guaC | HMPREF0548_1910 | HMPREF0548_1455 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.949 |
| EEJ71178.1 | hpt-2 | HMPREF0548_1910 | HMPREF0548_1123 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Hypoxanthine phosphoribosyltransferase; COG: COG0634; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.942 |
| EEJ71178.1 | rdgB | HMPREF0548_1910 | HMPREF0548_2195 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.953 |
| EEJ71178.1 | xpt | HMPREF0548_1910 | HMPREF0548_1981 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.949 |
| EEJ71572.1 | EEJ71178.1 | HMPREF0548_1592 | HMPREF0548_1910 | Guanylate kinase; COG: COG0194. | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.470 |
| EEJ71572.1 | apt | HMPREF0548_1592 | HMPREF0548_0107 | Guanylate kinase; COG: COG0194. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.963 |
| EEJ71572.1 | gmk | HMPREF0548_1592 | HMPREF0548_0828 | Guanylate kinase; COG: COG0194. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.953 |
| EEJ71572.1 | guaA | HMPREF0548_1592 | HMPREF0548_1982 | Guanylate kinase; COG: COG0194. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.983 |
| EEJ71572.1 | guaC | HMPREF0548_1592 | HMPREF0548_1455 | Guanylate kinase; COG: COG0194. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. | 0.943 |
| EEJ71572.1 | hpt-2 | HMPREF0548_1592 | HMPREF0548_1123 | Guanylate kinase; COG: COG0194. | Hypoxanthine phosphoribosyltransferase; COG: COG0634; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.941 |
| EEJ71572.1 | rdgB | HMPREF0548_1592 | HMPREF0548_2195 | Guanylate kinase; COG: COG0194. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.571 |
| EEJ71572.1 | xpt | HMPREF0548_1592 | HMPREF0548_1981 | Guanylate kinase; COG: COG0194. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.961 |
| EEJ72231.1 | apt | HMPREF0548_0918 | HMPREF0548_0107 | Inosine-uridine preferring nucleoside hydrolase; COG: COG1957. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.940 |
| EEJ72231.1 | hpt-2 | HMPREF0548_0918 | HMPREF0548_1123 | Inosine-uridine preferring nucleoside hydrolase; COG: COG1957. | Hypoxanthine phosphoribosyltransferase; COG: COG0634; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.963 |
| EEJ72231.1 | xpt | HMPREF0548_0918 | HMPREF0548_1981 | Inosine-uridine preferring nucleoside hydrolase; COG: COG1957. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.972 |
| apt | EEJ71178.1 | HMPREF0548_0107 | HMPREF0548_1910 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.529 |