node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEJ71213.1 | EEJ71846.1 | HMPREF0548_1945 | HMPREF0548_1262 | Hsp20/alpha crystallin family protein; COG: COG0071; Belongs to the small heat shock protein (HSP20) family. | Hypothetical protein. | 0.628 |
EEJ71213.1 | clpC | HMPREF0548_1945 | HMPREF0548_2035 | Hsp20/alpha crystallin family protein; COG: COG0071; Belongs to the small heat shock protein (HSP20) family. | ATPase family associated with various cellular activities (AAA); COG: COG0542; Belongs to the ClpA/ClpB family. | 0.819 |
EEJ71213.1 | clpP | HMPREF0548_1945 | HMPREF0548_0727 | Hsp20/alpha crystallin family protein; COG: COG0071; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.404 |
EEJ71213.1 | dnaJ | HMPREF0548_1945 | HMPREF0548_0113 | Hsp20/alpha crystallin family protein; COG: COG0071; Belongs to the small heat shock protein (HSP20) family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.794 |
EEJ71213.1 | dnaK | HMPREF0548_1945 | HMPREF0548_0114 | Hsp20/alpha crystallin family protein; COG: COG0071; Belongs to the small heat shock protein (HSP20) family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.731 |
EEJ71213.1 | grpE | HMPREF0548_1945 | HMPREF0548_0115 | Hsp20/alpha crystallin family protein; COG: COG0071; Belongs to the small heat shock protein (HSP20) family. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.636 |
EEJ71846.1 | EEJ71213.1 | HMPREF0548_1262 | HMPREF0548_1945 | Hypothetical protein. | Hsp20/alpha crystallin family protein; COG: COG0071; Belongs to the small heat shock protein (HSP20) family. | 0.628 |
EEJ71846.1 | clpC | HMPREF0548_1262 | HMPREF0548_2035 | Hypothetical protein. | ATPase family associated with various cellular activities (AAA); COG: COG0542; Belongs to the ClpA/ClpB family. | 0.908 |
EEJ71846.1 | clpP | HMPREF0548_1262 | HMPREF0548_0727 | Hypothetical protein. | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.672 |
EEJ71846.1 | dnaJ | HMPREF0548_1262 | HMPREF0548_0113 | Hypothetical protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.961 |
EEJ71846.1 | groS | HMPREF0548_1262 | HMPREF0548_2154 | Hypothetical protein. | Chaperonin GroS; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.828 |
EEJ71846.1 | grpE | HMPREF0548_1262 | HMPREF0548_0115 | Hypothetical protein. | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.952 |
EEJ72443.1 | clpC | HMPREF0548_0679 | HMPREF0548_2035 | Negative regulator of genetic competence (MecA); Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family. | ATPase family associated with various cellular activities (AAA); COG: COG0542; Belongs to the ClpA/ClpB family. | 0.786 |
clpC | EEJ71213.1 | HMPREF0548_2035 | HMPREF0548_1945 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Belongs to the ClpA/ClpB family. | Hsp20/alpha crystallin family protein; COG: COG0071; Belongs to the small heat shock protein (HSP20) family. | 0.819 |
clpC | EEJ71846.1 | HMPREF0548_2035 | HMPREF0548_1262 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Belongs to the ClpA/ClpB family. | Hypothetical protein. | 0.908 |
clpC | EEJ72443.1 | HMPREF0548_2035 | HMPREF0548_0679 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Belongs to the ClpA/ClpB family. | Negative regulator of genetic competence (MecA); Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family. | 0.786 |
clpC | clpP | HMPREF0548_2035 | HMPREF0548_0727 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Belongs to the ClpA/ClpB family. | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.948 |
clpC | clpX | HMPREF0548_2035 | HMPREF0548_0900 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.767 |
clpC | dnaJ | HMPREF0548_2035 | HMPREF0548_0113 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.894 |
clpC | dnaK | HMPREF0548_2035 | HMPREF0548_0114 | ATPase family associated with various cellular activities (AAA); COG: COG0542; Belongs to the ClpA/ClpB family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.953 |