| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EEJ71154.1 | cysS | HMPREF0548_2097 | HMPREF0548_2095 | RNA methyltransferase, TrmH family, group 3; COG: COG0566; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | cysteine--tRNA ligase; Cycrs; COG: COG0215; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.962 |
| EEJ71154.1 | gltX | HMPREF0548_2097 | HMPREF0548_2094 | RNA methyltransferase, TrmH family, group 3; COG: COG0566; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | 0.736 |
| EEJ71154.1 | mrnC | HMPREF0548_2097 | HMPREF0548_2096 | RNA methyltransferase, TrmH family, group 3; COG: COG0566; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | RNase3 domain protein; Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors; Belongs to the MrnC RNase family. | 0.964 |
| cysK | cysS | HMPREF0548_0103 | HMPREF0548_2095 | Cysteine synthase A; COG: COG0031; Belongs to the cysteine synthase/cystathionine beta- synthase family. | cysteine--tRNA ligase; Cycrs; COG: COG0215; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.971 |
| cysK | gltX | HMPREF0548_0103 | HMPREF0548_2094 | Cysteine synthase A; COG: COG0031; Belongs to the cysteine synthase/cystathionine beta- synthase family. | glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | 0.449 |
| cysK | glyA | HMPREF0548_0103 | HMPREF0548_2006 | Cysteine synthase A; COG: COG0031; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.734 |
| cysS | EEJ71154.1 | HMPREF0548_2095 | HMPREF0548_2097 | cysteine--tRNA ligase; Cycrs; COG: COG0215; Belongs to the class-I aminoacyl-tRNA synthetase family. | RNA methyltransferase, TrmH family, group 3; COG: COG0566; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | 0.962 |
| cysS | cysK | HMPREF0548_2095 | HMPREF0548_0103 | cysteine--tRNA ligase; Cycrs; COG: COG0215; Belongs to the class-I aminoacyl-tRNA synthetase family. | Cysteine synthase A; COG: COG0031; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.971 |
| cysS | gltX | HMPREF0548_2095 | HMPREF0548_2094 | cysteine--tRNA ligase; Cycrs; COG: COG0215; Belongs to the class-I aminoacyl-tRNA synthetase family. | glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | 0.779 |
| cysS | glyA | HMPREF0548_2095 | HMPREF0548_2006 | cysteine--tRNA ligase; Cycrs; COG: COG0215; Belongs to the class-I aminoacyl-tRNA synthetase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.712 |
| cysS | leuS | HMPREF0548_2095 | HMPREF0548_0444 | cysteine--tRNA ligase; Cycrs; COG: COG0215; Belongs to the class-I aminoacyl-tRNA synthetase family. | leucine--tRNA ligase; COG: COG0495; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.747 |
| cysS | mrnC | HMPREF0548_2095 | HMPREF0548_2096 | cysteine--tRNA ligase; Cycrs; COG: COG0215; Belongs to the class-I aminoacyl-tRNA synthetase family. | RNase3 domain protein; Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors; Belongs to the MrnC RNase family. | 0.970 |
| cysS | nusG | HMPREF0548_2095 | HMPREF0548_2104 | cysteine--tRNA ligase; Cycrs; COG: COG0215; Belongs to the class-I aminoacyl-tRNA synthetase family. | Transcription termination/antitermination factor NusG; Participates in transcription elongation, termination and antitermination. | 0.765 |
| cysS | polA | HMPREF0548_2095 | HMPREF0548_0360 | cysteine--tRNA ligase; Cycrs; COG: COG0215; Belongs to the class-I aminoacyl-tRNA synthetase family. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.750 |
| cysS | serS | HMPREF0548_2095 | HMPREF0548_1701 | cysteine--tRNA ligase; Cycrs; COG: COG0215; Belongs to the class-I aminoacyl-tRNA synthetase family. | serine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). | 0.759 |
| cysS | tpiA | HMPREF0548_2095 | HMPREF0548_0733 | cysteine--tRNA ligase; Cycrs; COG: COG0215; Belongs to the class-I aminoacyl-tRNA synthetase family. | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. | 0.802 |
| gltX | EEJ71154.1 | HMPREF0548_2094 | HMPREF0548_2097 | glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | RNA methyltransferase, TrmH family, group 3; COG: COG0566; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. | 0.736 |
| gltX | cysK | HMPREF0548_2094 | HMPREF0548_0103 | glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | Cysteine synthase A; COG: COG0031; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.449 |
| gltX | cysS | HMPREF0548_2094 | HMPREF0548_2095 | glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | cysteine--tRNA ligase; Cycrs; COG: COG0215; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.779 |
| gltX | glyA | HMPREF0548_2094 | HMPREF0548_2006 | glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.575 |