STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PksGhydroxymethylglutaryl-CoA synthase; COG: COG3425; Pfam: PF01154,PF08540; InterPro: IPR011554. (385 aa)    
Predicted Functional Partners:
atoB
hydroxymethylglutaryl-CoA reductase, degradative; Pfam: PF00108,PF02803; InterPro: IPR004553.
 0.999
atoB2
acetyl-CoA C-acetyltransferase; COG: COG0183; Pfam: PF00108,PF02803; InterPro: IPR002155; Belongs to the thiolase-like superfamily. Thiolase family.
 
 
 0.930
mvaD
Diphosphomevalonate decarboxylase; COG: COG3407; Pfam: PF00288,PF08544; InterPro: IPR005935.
 
 
 0.916
pflB
Formate C-acetyltransferase; COG: COG1882; Pfam: PF02901,PF01228; InterPro: IPR005949.
    
  0.901
mvk
Mevalonate kinase; COG: COG1577; Pfam: PF00288,PF08544; InterPro: IPR006205.
 
  
 0.852
EFI85086.1
Phosphomevalonate kinase; COG: COG1577; Pfam: PF00288,PF08544; InterPro: IPR005917.
 
  
 0.844
gltA
2-methylcitrate synthase/citrate synthase II; COG: COG0372; Pfam: PF00285; InterPro: IPR011278; Belongs to the citrate synthase family.
    
 0.819
pdhC
Putative dihydrolipoyllysine-residue acetyltransferase; COG: COG0508; Pfam: PF00364,PF02817,PF00198; InterPro: IPR001078.
   
 
 0.809
fni
Isopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
 
  
 0.780
EFI82986.1
Hydrolase, NUDIX family; Pfam: PF00293; InterPro: IPR000086.
  
  
 0.748
Your Current Organism:
Listeria grayi
NCBI taxonomy Id: 525367
Other names: L. grayi DSM 20601, Listeria grayi ATCC 19120, Listeria grayi DSM 20601, Listeria grayi str. DSM 20601, Listeria grayi strain DSM 20601
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.