| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cmk | der | HMPREF0556_11084 | HMPREF0556_11087 | Cytidylate kinase; COG: COG0283; Pfam: PF01202,PF02224; InterPro: IPR003136. | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.984 |
| cmk | ffh | HMPREF0556_11084 | HMPREF0556_11231 | Cytidylate kinase; COG: COG0283; Pfam: PF01202,PF02224; InterPro: IPR003136. | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.632 |
| cmk | gmk | HMPREF0556_11084 | HMPREF0556_11200 | Cytidylate kinase; COG: COG0283; Pfam: PF01202,PF02224; InterPro: IPR003136. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.444 |
| cmk | gpsA | HMPREF0556_11084 | HMPREF0556_11088 | Cytidylate kinase; COG: COG0283; Pfam: PF01202,PF02224; InterPro: IPR003136. | Glycerol-3-phosphate dehydrogenase [NAD(P)+]; COG: COG0240; Pfam: PF01210,PF07479; InterPro: IPR006168; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.509 |
| cmk | rluB | HMPREF0556_11084 | HMPREF0556_11074 | Cytidylate kinase; COG: COG0283; Pfam: PF01202,PF02224; InterPro: IPR003136. | Pseudouridine synthase B, ribosomal large subunit; COG: COG1187; Pfam: PF01479,PF00849; InterPro: IPR000748; Belongs to the pseudouridine synthase RsuA family. | 0.848 |
| cmk | rsuA | HMPREF0556_11084 | HMPREF0556_11545 | Cytidylate kinase; COG: COG0283; Pfam: PF01202,PF02224; InterPro: IPR003136. | Pseudouridylate synthase; COG: COG1187; Pfam: PF01479,PF00849; InterPro: IPR000748; Belongs to the pseudouridine synthase RsuA family. | 0.691 |
| cmk | scpB | HMPREF0556_11084 | HMPREF0556_11073 | Cytidylate kinase; COG: COG0283; Pfam: PF01202,PF02224; InterPro: IPR003136. | Segregation and condensation protein B; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. | 0.756 |
| der | cmk | HMPREF0556_11087 | HMPREF0556_11084 | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Cytidylate kinase; COG: COG0283; Pfam: PF01202,PF02224; InterPro: IPR003136. | 0.984 |
| der | dnaG | HMPREF0556_11087 | HMPREF0556_12351 | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.932 |
| der | ffh | HMPREF0556_11087 | HMPREF0556_11231 | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.593 |
| der | ftsY | HMPREF0556_11087 | HMPREF0556_11229 | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.694 |
| der | gmk | HMPREF0556_11087 | HMPREF0556_11200 | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.652 |
| der | gpsA | HMPREF0556_11087 | HMPREF0556_11088 | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Glycerol-3-phosphate dehydrogenase [NAD(P)+]; COG: COG0240; Pfam: PF01210,PF07479; InterPro: IPR006168; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. | 0.981 |
| der | rluB | HMPREF0556_11087 | HMPREF0556_11074 | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Pseudouridine synthase B, ribosomal large subunit; COG: COG1187; Pfam: PF01479,PF00849; InterPro: IPR000748; Belongs to the pseudouridine synthase RsuA family. | 0.827 |
| der | rsuA | HMPREF0556_11087 | HMPREF0556_11545 | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Pseudouridylate synthase; COG: COG1187; Pfam: PF01479,PF00849; InterPro: IPR000748; Belongs to the pseudouridine synthase RsuA family. | 0.681 |
| der | scpB | HMPREF0556_11087 | HMPREF0556_11073 | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Segregation and condensation protein B; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. | 0.602 |
| der | typA | HMPREF0556_11087 | HMPREF0556_11963 | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | GTP-binding protein TypA; COG: COG1217; Pfam: PF00009,PF03144,PF00679; InterPro: IPR006298. | 0.728 |
| dnaG | der | HMPREF0556_12351 | HMPREF0556_11087 | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.932 |
| ffh | cmk | HMPREF0556_11231 | HMPREF0556_11084 | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Cytidylate kinase; COG: COG0283; Pfam: PF01202,PF02224; InterPro: IPR003136. | 0.632 |
| ffh | der | HMPREF0556_11231 | HMPREF0556_11087 | Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Ribosome biogenesis GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.593 |