node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFK56035.1 | EFK56251.1 | HMPREF0766_13238 | HMPREF0766_13454 | Hypothetical protein; Pfam: PF02518. | MutS domain V protein; COG: COG0249; Pfam: PF00488; InterPro: IPR000432. | 0.989 |
EFK56035.1 | dnaN | HMPREF0766_13238 | HMPREF0766_10922 | Hypothetical protein; Pfam: PF02518. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.958 |
EFK56035.1 | mutS | HMPREF0766_13238 | HMPREF0766_10228 | Hypothetical protein; Pfam: PF02518. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.989 |
EFK56035.1 | polA | HMPREF0766_13238 | HMPREF0766_11917 | Hypothetical protein; Pfam: PF02518. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.995 |
EFK56035.1 | recQ | HMPREF0766_13238 | HMPREF0766_11977 | Hypothetical protein; Pfam: PF02518. | ATP-dependent DNA helicase RecQ; COG: COG0514; Pfam: PF00270,PF00271,PF00570; InterPro: IPR004589. | 0.890 |
EFK56035.1 | recQ2 | HMPREF0766_13238 | HMPREF0766_14429 | Hypothetical protein; Pfam: PF02518. | ATP-dependent DNA helicase, RecQ family; COG: COG0514; Pfam: PF00270,PF00271; InterPro: IPR004589. | 0.890 |
EFK56251.1 | EFK56035.1 | HMPREF0766_13454 | HMPREF0766_13238 | MutS domain V protein; COG: COG0249; Pfam: PF00488; InterPro: IPR000432. | Hypothetical protein; Pfam: PF02518. | 0.989 |
EFK56251.1 | dnaN | HMPREF0766_13454 | HMPREF0766_10922 | MutS domain V protein; COG: COG0249; Pfam: PF00488; InterPro: IPR000432. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.994 |
EFK56251.1 | mutL | HMPREF0766_13454 | HMPREF0766_11667 | MutS domain V protein; COG: COG0249; Pfam: PF00488; InterPro: IPR000432. | DNA mismatch repair domain protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.996 |
EFK56251.1 | mutS | HMPREF0766_13454 | HMPREF0766_10228 | MutS domain V protein; COG: COG0249; Pfam: PF00488; InterPro: IPR000432. | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.897 |
EFK56251.1 | mutS-2 | HMPREF0766_13454 | HMPREF0766_13597 | MutS domain V protein; COG: COG0249; Pfam: PF00488; InterPro: IPR000432. | MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. | 0.925 |
EFK56251.1 | polA | HMPREF0766_13454 | HMPREF0766_11917 | MutS domain V protein; COG: COG0249; Pfam: PF00488; InterPro: IPR000432. | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.995 |
EFK56251.1 | recQ | HMPREF0766_13454 | HMPREF0766_11977 | MutS domain V protein; COG: COG0249; Pfam: PF00488; InterPro: IPR000432. | ATP-dependent DNA helicase RecQ; COG: COG0514; Pfam: PF00270,PF00271,PF00570; InterPro: IPR004589. | 0.656 |
EFK56251.1 | recQ2 | HMPREF0766_13454 | HMPREF0766_14429 | MutS domain V protein; COG: COG0249; Pfam: PF00488; InterPro: IPR000432. | ATP-dependent DNA helicase, RecQ family; COG: COG0514; Pfam: PF00270,PF00271; InterPro: IPR004589. | 0.656 |
dnaN | EFK56035.1 | HMPREF0766_10922 | HMPREF0766_13238 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Hypothetical protein; Pfam: PF02518. | 0.958 |
dnaN | EFK56251.1 | HMPREF0766_10922 | HMPREF0766_13454 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | MutS domain V protein; COG: COG0249; Pfam: PF00488; InterPro: IPR000432. | 0.994 |
dnaN | mutL | HMPREF0766_10922 | HMPREF0766_11667 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair domain protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.965 |
dnaN | mutS | HMPREF0766_10922 | HMPREF0766_10228 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | 0.996 |
dnaN | polA | HMPREF0766_10922 | HMPREF0766_11917 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.999 |
dnaN | priA | HMPREF0766_10922 | HMPREF0766_11037 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.453 |