node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aroC | pabA | HMPREF0766_12835 | HMPREF0766_10493 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | 0.981 |
aroC | pchB | HMPREF0766_12835 | HMPREF0766_10492 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Salicylate biosynthesis protein PchB; Pfam: PF01817; InterPro: IPR002701. | 0.818 |
aroC | pheB | HMPREF0766_12835 | HMPREF0766_12837 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Putative 3-deoxy-7-phosphoheptulonate synthase; COG: COG2876; Pfam: PF00793,PF01817; InterPro: IPR006268. | 0.999 |
aroC | trpA | HMPREF0766_12835 | HMPREF0766_10151 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.840 |
aroC | trpB | HMPREF0766_12835 | HMPREF0766_10150 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.628 |
aroC | trpC | HMPREF0766_12835 | HMPREF0766_10494 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Indole-3-glycerol phosphate synthase; COG: COG0134; Pfam: PF00218; InterPro: IPR013785; Belongs to the TrpC family. | 0.703 |
aroC | trpD | HMPREF0766_12835 | HMPREF0766_10148 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.767 |
aroC | trpE | HMPREF0766_12835 | HMPREF0766_13707 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Chorismate binding enzyme; COG: COG0147; Pfam: PF00425; InterPro: IPR005801. | 0.955 |
aroC | trpE2 | HMPREF0766_12835 | HMPREF0766_10491 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Chorismate binding enzyme; COG: COG0147; Pfam: PF04715,PF00425; InterPro: IPR005801. | 0.976 |
aroC | trpF | HMPREF0766_12835 | HMPREF0766_10149 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | N-(5'phosphoribosyl)anthranilate isomerase; COG: COG0135; Pfam: PF00697; InterPro: IPR013785; Belongs to the TrpF family. | 0.653 |
pabA | aroC | HMPREF0766_10493 | HMPREF0766_12835 | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.981 |
pabA | pchB | HMPREF0766_10493 | HMPREF0766_10492 | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | Salicylate biosynthesis protein PchB; Pfam: PF01817; InterPro: IPR002701. | 0.902 |
pabA | pheB | HMPREF0766_10493 | HMPREF0766_12837 | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | Putative 3-deoxy-7-phosphoheptulonate synthase; COG: COG2876; Pfam: PF00793,PF01817; InterPro: IPR006268. | 0.971 |
pabA | trpA | HMPREF0766_10493 | HMPREF0766_10151 | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.990 |
pabA | trpB | HMPREF0766_10493 | HMPREF0766_10150 | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.991 |
pabA | trpC | HMPREF0766_10493 | HMPREF0766_10494 | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | Indole-3-glycerol phosphate synthase; COG: COG0134; Pfam: PF00218; InterPro: IPR013785; Belongs to the TrpC family. | 0.999 |
pabA | trpD | HMPREF0766_10493 | HMPREF0766_10148 | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
pabA | trpE | HMPREF0766_10493 | HMPREF0766_13707 | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | Chorismate binding enzyme; COG: COG0147; Pfam: PF00425; InterPro: IPR005801. | 0.999 |
pabA | trpE2 | HMPREF0766_10493 | HMPREF0766_10491 | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | Chorismate binding enzyme; COG: COG0147; Pfam: PF04715,PF00425; InterPro: IPR005801. | 0.999 |
pabA | trpF | HMPREF0766_10493 | HMPREF0766_10149 | Glutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. | N-(5'phosphoribosyl)anthranilate isomerase; COG: COG0135; Pfam: PF00697; InterPro: IPR013785; Belongs to the TrpF family. | 0.991 |