node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFK58405.1 | kdsA | HMPREF0766_11801 | HMPREF0766_11976 | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Pfam: PF03279; InterPro: IPR004960. | 3-deoxy-8-phosphooctulonate synthase; COG: COG2877; Pfam: PF00793; InterPro: IPR006218; Belongs to the KdsA family. | 0.623 |
EFK58405.1 | kdsB | HMPREF0766_11801 | HMPREF0766_13165 | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Pfam: PF03279; InterPro: IPR004960. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.747 |
EFK58405.1 | kdsD | HMPREF0766_11801 | HMPREF0766_11978 | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Pfam: PF03279; InterPro: IPR004960. | Sugar isomerase, KpsF/GutQ family; COG: COG0794; Pfam: PF01380,PF00571; InterPro: IPR004800; Belongs to the SIS family. GutQ/KpsF subfamily. | 0.715 |
EFK58405.1 | lpxA | HMPREF0766_11801 | HMPREF0766_10538 | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Pfam: PF03279; InterPro: IPR004960. | acyl-[acyl-carrier-protein]-UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.778 |
EFK58405.1 | lpxB | HMPREF0766_11801 | HMPREF0766_14009 | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Pfam: PF03279; InterPro: IPR004960. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.795 |
EFK58405.1 | lpxC | HMPREF0766_11801 | HMPREF0766_10539 | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Pfam: PF03279; InterPro: IPR004960. | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. | 0.786 |
EFK58405.1 | lpxD | HMPREF0766_11801 | HMPREF0766_10540 | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Pfam: PF03279; InterPro: IPR004960. | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.777 |
EFK58405.1 | lpxK | HMPREF0766_11801 | HMPREF0766_10928 | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Pfam: PF03279; InterPro: IPR004960. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.868 |
EFK58405.1 | waaA | HMPREF0766_11801 | HMPREF0766_10639 | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Pfam: PF03279; InterPro: IPR004960. | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.930 |
kdsA | EFK58405.1 | HMPREF0766_11976 | HMPREF0766_11801 | 3-deoxy-8-phosphooctulonate synthase; COG: COG2877; Pfam: PF00793; InterPro: IPR006218; Belongs to the KdsA family. | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Pfam: PF03279; InterPro: IPR004960. | 0.623 |
kdsA | kdsB | HMPREF0766_11976 | HMPREF0766_13165 | 3-deoxy-8-phosphooctulonate synthase; COG: COG2877; Pfam: PF00793; InterPro: IPR006218; Belongs to the KdsA family. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.904 |
kdsA | kdsD | HMPREF0766_11976 | HMPREF0766_11978 | 3-deoxy-8-phosphooctulonate synthase; COG: COG2877; Pfam: PF00793; InterPro: IPR006218; Belongs to the KdsA family. | Sugar isomerase, KpsF/GutQ family; COG: COG0794; Pfam: PF01380,PF00571; InterPro: IPR004800; Belongs to the SIS family. GutQ/KpsF subfamily. | 0.996 |
kdsA | lpxA | HMPREF0766_11976 | HMPREF0766_10538 | 3-deoxy-8-phosphooctulonate synthase; COG: COG2877; Pfam: PF00793; InterPro: IPR006218; Belongs to the KdsA family. | acyl-[acyl-carrier-protein]-UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.788 |
kdsA | lpxB | HMPREF0766_11976 | HMPREF0766_14009 | 3-deoxy-8-phosphooctulonate synthase; COG: COG2877; Pfam: PF00793; InterPro: IPR006218; Belongs to the KdsA family. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.804 |
kdsA | lpxC | HMPREF0766_11976 | HMPREF0766_10539 | 3-deoxy-8-phosphooctulonate synthase; COG: COG2877; Pfam: PF00793; InterPro: IPR006218; Belongs to the KdsA family. | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. | 0.747 |
kdsA | lpxD | HMPREF0766_11976 | HMPREF0766_10540 | 3-deoxy-8-phosphooctulonate synthase; COG: COG2877; Pfam: PF00793; InterPro: IPR006218; Belongs to the KdsA family. | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.779 |
kdsA | lpxK | HMPREF0766_11976 | HMPREF0766_10928 | 3-deoxy-8-phosphooctulonate synthase; COG: COG2877; Pfam: PF00793; InterPro: IPR006218; Belongs to the KdsA family. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.821 |
kdsA | waaA | HMPREF0766_11976 | HMPREF0766_10639 | 3-deoxy-8-phosphooctulonate synthase; COG: COG2877; Pfam: PF00793; InterPro: IPR006218; Belongs to the KdsA family. | 3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.813 |
kdsB | EFK58405.1 | HMPREF0766_13165 | HMPREF0766_11801 | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase; Pfam: PF03279; InterPro: IPR004960. | 0.747 |
kdsB | kdsA | HMPREF0766_13165 | HMPREF0766_11976 | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 3-deoxy-8-phosphooctulonate synthase; COG: COG2877; Pfam: PF00793; InterPro: IPR006218; Belongs to the KdsA family. | 0.904 |