| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFK57140.1 | acsA | HMPREF0766_12213 | HMPREF0766_11124 | Succinate CoA transferase; COG: COG0427; Pfam: PF02550; InterPro: IPR003702. | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.960 |
| EFK57140.1 | aldA | HMPREF0766_12213 | HMPREF0766_11031 | Succinate CoA transferase; COG: COG0427; Pfam: PF02550; InterPro: IPR003702. | Aldehyde dehydrogenase (NAD) family protein; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 0.938 |
| EFK57140.1 | alh | HMPREF0766_12213 | HMPREF0766_11640 | Succinate CoA transferase; COG: COG0427; Pfam: PF02550; InterPro: IPR003702. | Aldehyde dehydrogenase (NAD) family protein; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 0.938 |
| EFK57140.1 | alkH | HMPREF0766_12213 | HMPREF0766_10797 | Succinate CoA transferase; COG: COG0427; Pfam: PF02550; InterPro: IPR003702. | Aldehyde dehydrogenase; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 0.848 |
| EFK57140.1 | poxB | HMPREF0766_12213 | HMPREF0766_12882 | Succinate CoA transferase; COG: COG0427; Pfam: PF02550; InterPro: IPR003702. | Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; COG: COG0028; Pfam: PF02776,PF00205,PF02775; InterPro: IPR012001; Belongs to the TPP enzyme family. | 0.672 |
| EFK58917.1 | adhA | HMPREF0766_11033 | HMPREF0766_11032 | Hypothetical protein; COG: COG3564; Pfam: PF05610; InterPro: IPR008497; 5.1.3.2. | GroES-like protein; COG: COG1064; Pfam: PF08240,PF00107; InterPro: IPR002085. | 0.752 |
| EFK58917.1 | aldA | HMPREF0766_11033 | HMPREF0766_11031 | Hypothetical protein; COG: COG3564; Pfam: PF05610; InterPro: IPR008497; 5.1.3.2. | Aldehyde dehydrogenase (NAD) family protein; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 0.907 |
| acsA | EFK57140.1 | HMPREF0766_11124 | HMPREF0766_12213 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Succinate CoA transferase; COG: COG0427; Pfam: PF02550; InterPro: IPR003702. | 0.960 |
| acsA | acyP | HMPREF0766_11124 | HMPREF0766_10504 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Acylphosphatase; COG: COG1254; Pfam: PF00708; InterPro: IPR001792. | 0.936 |
| acsA | aldA | HMPREF0766_11124 | HMPREF0766_11031 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Aldehyde dehydrogenase (NAD) family protein; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 0.955 |
| acsA | alh | HMPREF0766_11124 | HMPREF0766_11640 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Aldehyde dehydrogenase (NAD) family protein; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 0.955 |
| acsA | alkH | HMPREF0766_11124 | HMPREF0766_10797 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Aldehyde dehydrogenase; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 0.891 |
| acsA | gltB | HMPREF0766_11124 | HMPREF0766_10210 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Class II glutamine amidotransferase; COG: COG0069; Pfam: PF00310,PF04898,PF01645,PF01493; InterPro: IPR013785. | 0.616 |
| acsA | poxB | HMPREF0766_11124 | HMPREF0766_12882 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; COG: COG0028; Pfam: PF02776,PF00205,PF02775; InterPro: IPR012001; Belongs to the TPP enzyme family. | 0.942 |
| acyP | acsA | HMPREF0766_10504 | HMPREF0766_11124 | Acylphosphatase; COG: COG1254; Pfam: PF00708; InterPro: IPR001792. | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.936 |
| acyP | aldA | HMPREF0766_10504 | HMPREF0766_11031 | Acylphosphatase; COG: COG1254; Pfam: PF00708; InterPro: IPR001792. | Aldehyde dehydrogenase (NAD) family protein; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 0.937 |
| acyP | alh | HMPREF0766_10504 | HMPREF0766_11640 | Acylphosphatase; COG: COG1254; Pfam: PF00708; InterPro: IPR001792. | Aldehyde dehydrogenase (NAD) family protein; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 0.937 |
| acyP | alkH | HMPREF0766_10504 | HMPREF0766_10797 | Acylphosphatase; COG: COG1254; Pfam: PF00708; InterPro: IPR001792. | Aldehyde dehydrogenase; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 0.846 |
| adh | adhA | HMPREF0766_13005 | HMPREF0766_11032 | GroES-like protein; COG: COG1064; Pfam: PF08240,PF00107; InterPro: IPR002085. | GroES-like protein; COG: COG1064; Pfam: PF08240,PF00107; InterPro: IPR002085. | 0.670 |
| adh | aldA | HMPREF0766_13005 | HMPREF0766_11031 | GroES-like protein; COG: COG1064; Pfam: PF08240,PF00107; InterPro: IPR002085. | Aldehyde dehydrogenase (NAD) family protein; COG: COG1012; Pfam: PF00171; InterPro: IPR015590; Belongs to the aldehyde dehydrogenase family. | 0.906 |