| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFK58847.1 | ppnK | HMPREF0766_11564 | HMPREF0766_11563 | Outer membrane insertion signal domain protein. | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.722 |
| EFK58847.1 | uppS | HMPREF0766_11564 | HMPREF0766_11565 | Outer membrane insertion signal domain protein. | Di-trans,poly-cis-decaprenylcistransferase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.802 |
| cdsA-3 | dxr | HMPREF0766_10950 | HMPREF0766_12898 | Phosphatidate cytidylyltransferase; COG: COG0575; Pfam: PF01148; InterPro: IPR000374. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.797 |
| cdsA-3 | uppS | HMPREF0766_10950 | HMPREF0766_11565 | Phosphatidate cytidylyltransferase; COG: COG0575; Pfam: PF01148; InterPro: IPR000374. | Di-trans,poly-cis-decaprenylcistransferase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.941 |
| crtB | gds | HMPREF0766_11524 | HMPREF0766_11104 | Phytoene/squalene synthetase; COG: COG1562; Pfam: PF00494; InterPro: IPR002060. | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | 0.925 |
| crtB | hepT | HMPREF0766_11524 | HMPREF0766_10345 | Phytoene/squalene synthetase; COG: COG1562; Pfam: PF00494; InterPro: IPR002060. | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | 0.925 |
| crtB | uppS | HMPREF0766_11524 | HMPREF0766_11565 | Phytoene/squalene synthetase; COG: COG1562; Pfam: PF00494; InterPro: IPR002060. | Di-trans,poly-cis-decaprenylcistransferase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.854 |
| dxr | cdsA-3 | HMPREF0766_12898 | HMPREF0766_10950 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | Phosphatidate cytidylyltransferase; COG: COG0575; Pfam: PF01148; InterPro: IPR000374. | 0.797 |
| dxr | frr | HMPREF0766_12898 | HMPREF0766_12253 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | 0.412 |
| dxr | proS | HMPREF0766_12898 | HMPREF0766_12114 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). | 0.449 |
| dxr | uppS | HMPREF0766_12898 | HMPREF0766_11565 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | Di-trans,poly-cis-decaprenylcistransferase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.932 |
| frr | dxr | HMPREF0766_12253 | HMPREF0766_12898 | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.412 |
| frr | proS | HMPREF0766_12253 | HMPREF0766_12114 | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | proline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). | 0.406 |
| frr | uppS | HMPREF0766_12253 | HMPREF0766_11565 | Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | Di-trans,poly-cis-decaprenylcistransferase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.817 |
| gds | crtB | HMPREF0766_11104 | HMPREF0766_11524 | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | Phytoene/squalene synthetase; COG: COG1562; Pfam: PF00494; InterPro: IPR002060. | 0.925 |
| gds | hepT | HMPREF0766_11104 | HMPREF0766_10345 | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | 0.951 |
| gds | ppnK | HMPREF0766_11104 | HMPREF0766_11563 | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | NAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.469 |
| gds | uppS | HMPREF0766_11104 | HMPREF0766_11565 | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | Di-trans,poly-cis-decaprenylcistransferase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.985 |
| hepT | crtB | HMPREF0766_10345 | HMPREF0766_11524 | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | Phytoene/squalene synthetase; COG: COG1562; Pfam: PF00494; InterPro: IPR002060. | 0.925 |
| hepT | gds | HMPREF0766_10345 | HMPREF0766_11104 | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | Polyprenyl synthetase; COG: COG0142; Pfam: PF00348; InterPro: IPR008949; Belongs to the FPP/GGPP synthase family. | 0.951 |