STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folK2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; COG: COG0801; Pfam: PF01288; InterPro: IPR000550. (160 aa)    
Predicted Functional Partners:
folP
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
 0.999
folB
Dihydroneopterin aldolase; Pfam: PF02152; InterPro: IPR006157.
  
 
 0.995
folE
GTP cyclohydrolase I; COG: COG0302; Pfam: PF01227; InterPro: IPR001474.
 
  
 0.981
ribB
3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
 
 0.787
folC
Bifunctional protein FolC; COG: COG0285; Pfam: PF08245,PF02875; InterPro: IPR001645; Belongs to the folylpolyglutamate synthase family.
 
 
 0.784
trpE
Chorismate binding enzyme; COG: COG0147; Pfam: PF00425; InterPro: IPR005801.
 
 
 0.703
sppA
Signal peptide peptidase SppA, 67K type; COG: COG0616; Pfam: PF01343; InterPro: IPR004634.
       0.696
EFK60027.1
Dinuclear metal center protein, YbgI family; COG: COG3323; Pfam: PF01784; InterPro: IPR002678; Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
    
  0.693
EFK58880.1
Hypothetical protein.
       0.654
trpE2
Chorismate binding enzyme; COG: COG0147; Pfam: PF04715,PF00425; InterPro: IPR005801.
 
 
 0.623
Your Current Organism:
Sphingobacterium spiritivorum
NCBI taxonomy Id: 525373
Other names: S. spiritivorum ATCC 33861, Sphingobacterium spiritivorum ATCC 33861, Sphingobacterium spiritivorum str. ATCC 33861, Sphingobacterium spiritivorum strain ATCC 33861
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.