| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EFK56424.1 | acsA | HMPREF0766_13627 | HMPREF0766_11124 | enoyl-CoA hydratase/isomerase family protein; COG: COG1024; Pfam: PF00378; InterPro: IPR001753. | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.425 |
| EFK56424.1 | atoB2 | HMPREF0766_13627 | HMPREF0766_11700 | enoyl-CoA hydratase/isomerase family protein; COG: COG1024; Pfam: PF00378; InterPro: IPR001753. | acetyl-CoA C-acetyltransferase; COG: COG0183; Pfam: PF00108,PF02803; InterPro: IPR002155; Belongs to the thiolase-like superfamily. Thiolase family. | 0.967 |
| EFK56424.1 | fadB | HMPREF0766_13627 | HMPREF0766_11701 | enoyl-CoA hydratase/isomerase family protein; COG: COG1024; Pfam: PF00378; InterPro: IPR001753. | 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein; COG: COG1250; Pfam: PF02737,PF00725,PF00378; InterPro: IPR016040. | 0.663 |
| EFK56424.1 | fadJ | HMPREF0766_13627 | HMPREF0766_14112 | enoyl-CoA hydratase/isomerase family protein; COG: COG1024; Pfam: PF00378; InterPro: IPR001753. | 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein; COG: COG1250; Pfam: PF00378,PF02737,PF00725; InterPro: IPR016040. | 0.825 |
| EFK56424.1 | gcdH | HMPREF0766_13627 | HMPREF0766_12549 | enoyl-CoA hydratase/isomerase family protein; COG: COG1024; Pfam: PF00378; InterPro: IPR001753. | acyl-CoA dehydrogenase, C-terminal domain protein; COG: COG1960; Pfam: PF02771,PF02770,PF00441; InterPro: IPR013764. | 0.763 |
| EFK56424.1 | gcdH2 | HMPREF0766_13627 | HMPREF0766_11639 | enoyl-CoA hydratase/isomerase family protein; COG: COG1024; Pfam: PF00378; InterPro: IPR001753. | acyl-CoA dehydrogenase, C-terminal domain protein; COG: COG1960; Pfam: PF02771,PF02770,PF00441; InterPro: IPR013764. | 0.753 |
| EFK56424.1 | hmgcl | HMPREF0766_13627 | HMPREF0766_13626 | enoyl-CoA hydratase/isomerase family protein; COG: COG1024; Pfam: PF00378; InterPro: IPR001753. | HMGL-like protein; COG: COG0119; Pfam: PF00682; InterPro: IPR013785. | 0.990 |
| EFK56807.1 | atoB2 | HMPREF0766_14010 | HMPREF0766_11700 | Hypothetical protein. | acetyl-CoA C-acetyltransferase; COG: COG0183; Pfam: PF00108,PF02803; InterPro: IPR002155; Belongs to the thiolase-like superfamily. Thiolase family. | 0.960 |
| EFK56807.1 | fadB | HMPREF0766_14010 | HMPREF0766_11701 | Hypothetical protein. | 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein; COG: COG1250; Pfam: PF02737,PF00725,PF00378; InterPro: IPR016040. | 0.663 |
| EFK56807.1 | gcdH | HMPREF0766_14010 | HMPREF0766_12549 | Hypothetical protein. | acyl-CoA dehydrogenase, C-terminal domain protein; COG: COG1960; Pfam: PF02771,PF02770,PF00441; InterPro: IPR013764. | 0.582 |
| EFK56807.1 | gcdH2 | HMPREF0766_14010 | HMPREF0766_11639 | Hypothetical protein. | acyl-CoA dehydrogenase, C-terminal domain protein; COG: COG1960; Pfam: PF02771,PF02770,PF00441; InterPro: IPR013764. | 0.582 |
| EFK59955.1 | atoB2 | HMPREF0766_10872 | HMPREF0766_11700 | enoyl-CoA hydratase/isomerase family protein; Pfam: PF00378; InterPro: IPR001753; Belongs to the enoyl-CoA hydratase/isomerase family. | acetyl-CoA C-acetyltransferase; COG: COG0183; Pfam: PF00108,PF02803; InterPro: IPR002155; Belongs to the thiolase-like superfamily. Thiolase family. | 0.972 |
| EFK59955.1 | fadB | HMPREF0766_10872 | HMPREF0766_11701 | enoyl-CoA hydratase/isomerase family protein; Pfam: PF00378; InterPro: IPR001753; Belongs to the enoyl-CoA hydratase/isomerase family. | 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein; COG: COG1250; Pfam: PF02737,PF00725,PF00378; InterPro: IPR016040. | 0.719 |
| EFK59955.1 | fadJ | HMPREF0766_10872 | HMPREF0766_14112 | enoyl-CoA hydratase/isomerase family protein; Pfam: PF00378; InterPro: IPR001753; Belongs to the enoyl-CoA hydratase/isomerase family. | 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein; COG: COG1250; Pfam: PF00378,PF02737,PF00725; InterPro: IPR016040. | 0.837 |
| EFK59955.1 | gcdH | HMPREF0766_10872 | HMPREF0766_12549 | enoyl-CoA hydratase/isomerase family protein; Pfam: PF00378; InterPro: IPR001753; Belongs to the enoyl-CoA hydratase/isomerase family. | acyl-CoA dehydrogenase, C-terminal domain protein; COG: COG1960; Pfam: PF02771,PF02770,PF00441; InterPro: IPR013764. | 0.799 |
| EFK59955.1 | gcdH2 | HMPREF0766_10872 | HMPREF0766_11639 | enoyl-CoA hydratase/isomerase family protein; Pfam: PF00378; InterPro: IPR001753; Belongs to the enoyl-CoA hydratase/isomerase family. | acyl-CoA dehydrogenase, C-terminal domain protein; COG: COG1960; Pfam: PF02771,PF02770,PF00441; InterPro: IPR013764. | 0.847 |
| EFK59955.1 | hmgcl | HMPREF0766_10872 | HMPREF0766_13626 | enoyl-CoA hydratase/isomerase family protein; Pfam: PF00378; InterPro: IPR001753; Belongs to the enoyl-CoA hydratase/isomerase family. | HMGL-like protein; COG: COG0119; Pfam: PF00682; InterPro: IPR013785. | 0.578 |
| acsA | EFK56424.1 | HMPREF0766_11124 | HMPREF0766_13627 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | enoyl-CoA hydratase/isomerase family protein; COG: COG1024; Pfam: PF00378; InterPro: IPR001753. | 0.425 |
| acsA | atoB2 | HMPREF0766_11124 | HMPREF0766_11700 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | acetyl-CoA C-acetyltransferase; COG: COG0183; Pfam: PF00108,PF02803; InterPro: IPR002155; Belongs to the thiolase-like superfamily. Thiolase family. | 0.946 |
| acsA | fadB | HMPREF0766_11124 | HMPREF0766_11701 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein; COG: COG1250; Pfam: PF02737,PF00725,PF00378; InterPro: IPR016040. | 0.932 |