STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EFK57220.1Hypothetical protein. (283 aa)    
Predicted Functional Partners:
EFK57221.1
Hypothetical protein.
       0.555
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.511
EFK56302.1
Competence protein ComEA helix-hairpin-helix repeat region.
  
     0.493
EFK59411.1
STAS domain protein; Pfam: PF01740; InterPro: IPR002645.
  
     0.464
EFK55957.1
Hypothetical protein.
  
     0.447
EFK59680.1
Hypothetical protein.
  
     0.446
EFK58101.1
NHL repeat protein; Pfam: PF01436; InterPro: IPR011042.
  
     0.419
EFK60031.1
CAAX amino terminal protease family protein; Pfam: PF02517; InterPro: IPR003675.
  
     0.415
EFK57600.1
NHL repeat protein; Pfam: PF01833,PF01436; InterPro: IPR011042.
  
     0.413
EFK59403.1
WD domain, G-beta repeat protein; COG: COG2319; Pfam: PF00400; InterPro: IPR015943.
  
     0.402
Your Current Organism:
Sphingobacterium spiritivorum
NCBI taxonomy Id: 525373
Other names: S. spiritivorum ATCC 33861, Sphingobacterium spiritivorum ATCC 33861, Sphingobacterium spiritivorum str. ATCC 33861, Sphingobacterium spiritivorum strain ATCC 33861
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.