| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cinA | guaB | HMPREF0766_10131 | HMPREF0766_12858 | Competence/damage-inducible domain protein CinA; COG: COG1058; Pfam: PF00994,PF02464; InterPro: IPR008135; Belongs to the CinA family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.514 |
| cinA | pncB | HMPREF0766_10131 | HMPREF0766_14399 | Competence/damage-inducible domain protein CinA; COG: COG1058; Pfam: PF00994,PF02464; InterPro: IPR008135; Belongs to the CinA family. | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | 0.961 |
| cinA | yjjG | HMPREF0766_10131 | HMPREF0766_12372 | Competence/damage-inducible domain protein CinA; COG: COG1058; Pfam: PF00994,PF02464; InterPro: IPR008135; Belongs to the CinA family. | HAD hydrolase, TIGR02254 family; COG: COG1011; Pfam: PF00702; InterPro: IPR011951. | 0.810 |
| guaA | guaB | HMPREF0766_12148 | HMPREF0766_12858 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | punA | HMPREF0766_12148 | HMPREF0766_11807 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.569 |
| guaA | purA | HMPREF0766_12148 | HMPREF0766_13708 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.927 |
| guaA | udk | HMPREF0766_12148 | HMPREF0766_12120 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribulokinase/uridine kinase family protein; Pfam: PF00485; InterPro: IPR000764. | 0.421 |
| guaA | upp2 | HMPREF0766_12148 | HMPREF0766_11236 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Putative uracil phosphoribosyltransferase; COG: COG0035; Pfam: PF00156. | 0.944 |
| guaA | yjjG | HMPREF0766_12148 | HMPREF0766_12372 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | HAD hydrolase, TIGR02254 family; COG: COG1011; Pfam: PF00702; InterPro: IPR011951. | 0.805 |
| guaB | cinA | HMPREF0766_12858 | HMPREF0766_10131 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Competence/damage-inducible domain protein CinA; COG: COG1058; Pfam: PF00994,PF02464; InterPro: IPR008135; Belongs to the CinA family. | 0.514 |
| guaB | guaA | HMPREF0766_12858 | HMPREF0766_12148 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.999 |
| guaB | punA | HMPREF0766_12858 | HMPREF0766_11807 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.436 |
| guaB | purA | HMPREF0766_12858 | HMPREF0766_13708 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.994 |
| guaB | udk | HMPREF0766_12858 | HMPREF0766_12120 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribulokinase/uridine kinase family protein; Pfam: PF00485; InterPro: IPR000764. | 0.417 |
| guaB | yjjG | HMPREF0766_12858 | HMPREF0766_12372 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | HAD hydrolase, TIGR02254 family; COG: COG1011; Pfam: PF00702; InterPro: IPR011951. | 0.813 |
| pncB | cinA | HMPREF0766_14399 | HMPREF0766_10131 | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | Competence/damage-inducible domain protein CinA; COG: COG1058; Pfam: PF00994,PF02464; InterPro: IPR008135; Belongs to the CinA family. | 0.961 |
| pncB | punA | HMPREF0766_14399 | HMPREF0766_11807 | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. | 0.947 |
| pncB | udk | HMPREF0766_14399 | HMPREF0766_12120 | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | Phosphoribulokinase/uridine kinase family protein; Pfam: PF00485; InterPro: IPR000764. | 0.585 |
| pncB | udp | HMPREF0766_14399 | HMPREF0766_12842 | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | Phosphorylase family; COG: COG2820; Pfam: PF01048; InterPro: IPR000845. | 0.400 |
| pncB | yjjG | HMPREF0766_14399 | HMPREF0766_12372 | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. | HAD hydrolase, TIGR02254 family; COG: COG1011; Pfam: PF00702; InterPro: IPR011951. | 0.799 |