node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
guaA | guaB | HMPREF0766_12148 | HMPREF0766_12858 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | mgtE-2 | HMPREF0766_12148 | HMPREF0766_12881 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Magnesium transporter; Acts as a magnesium transporter. | 0.711 |
guaA | purA | HMPREF0766_12148 | HMPREF0766_13708 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.927 |
guaA | purH | HMPREF0766_12148 | HMPREF0766_12887 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG: COG0138; Pfam: PF02142,PF01808; InterPro: IPR002695. | 0.905 |
guaA | rdgB | HMPREF0766_12148 | HMPREF0766_10206 | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.983 |
guaB | guaA | HMPREF0766_12858 | HMPREF0766_12148 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.999 |
guaB | mgtE-2 | HMPREF0766_12858 | HMPREF0766_12881 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Magnesium transporter; Acts as a magnesium transporter. | 0.623 |
guaB | purA | HMPREF0766_12858 | HMPREF0766_13708 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.994 |
guaB | purH | HMPREF0766_12858 | HMPREF0766_12887 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG: COG0138; Pfam: PF02142,PF01808; InterPro: IPR002695. | 0.983 |
guaB | rdgB | HMPREF0766_12858 | HMPREF0766_10206 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.961 |
mgtE-2 | guaA | HMPREF0766_12881 | HMPREF0766_12148 | Magnesium transporter; Acts as a magnesium transporter. | GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP. | 0.711 |
mgtE-2 | guaB | HMPREF0766_12881 | HMPREF0766_12858 | Magnesium transporter; Acts as a magnesium transporter. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.623 |
mgtE-2 | pepE | HMPREF0766_12881 | HMPREF0766_12880 | Magnesium transporter; Acts as a magnesium transporter. | Putative dipeptidase E; COG: COG3340; Pfam: PF03575; InterPro: IPR005320; Belongs to the peptidase S51 family. | 0.618 |
mgtE-2 | poxB | HMPREF0766_12881 | HMPREF0766_12882 | Magnesium transporter; Acts as a magnesium transporter. | Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; COG: COG0028; Pfam: PF02776,PF00205,PF02775; InterPro: IPR012001; Belongs to the TPP enzyme family. | 0.529 |
mgtE-2 | purA | HMPREF0766_12881 | HMPREF0766_13708 | Magnesium transporter; Acts as a magnesium transporter. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.459 |
mgtE-2 | purH | HMPREF0766_12881 | HMPREF0766_12887 | Magnesium transporter; Acts as a magnesium transporter. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG: COG0138; Pfam: PF02142,PF01808; InterPro: IPR002695. | 0.422 |
mgtE-2 | rdgB | HMPREF0766_12881 | HMPREF0766_10206 | Magnesium transporter; Acts as a magnesium transporter. | Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.414 |
pepE | mgtE-2 | HMPREF0766_12880 | HMPREF0766_12881 | Putative dipeptidase E; COG: COG3340; Pfam: PF03575; InterPro: IPR005320; Belongs to the peptidase S51 family. | Magnesium transporter; Acts as a magnesium transporter. | 0.618 |
pepE | poxB | HMPREF0766_12880 | HMPREF0766_12882 | Putative dipeptidase E; COG: COG3340; Pfam: PF03575; InterPro: IPR005320; Belongs to the peptidase S51 family. | Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; COG: COG0028; Pfam: PF02776,PF00205,PF02775; InterPro: IPR012001; Belongs to the TPP enzyme family. | 0.427 |
poxB | mgtE-2 | HMPREF0766_12882 | HMPREF0766_12881 | Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; COG: COG0028; Pfam: PF02776,PF00205,PF02775; InterPro: IPR012001; Belongs to the TPP enzyme family. | Magnesium transporter; Acts as a magnesium transporter. | 0.529 |