STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemFCoproporphyrinogen III oxidase, aerobic; COG: COG0408; Pfam: PF01218; InterPro: IPR001260. (298 aa)    
Predicted Functional Partners:
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.987
EFK57305.1
TIGR00701 family protein; COG: COG1981; Pfam: PF03653; InterPro: IPR005265.
 
  
 0.966
EFK59710.1
Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
    
 0.949
hemN
Coproporphyrinogen dehydrogenase; COG: COG0635; Pfam: PF04055,PF06969; InterPro: IPR004558; Belongs to the anaerobic coproporphyrinogen-III oxidase family.
    
 0.949
gpsA
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminal domain protein; COG: COG0240; Pfam: PF01210,PF07479; InterPro: IPR006168; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
  
  
 0.803
EFK56499.1
Peptidase M16 inactive domain protein; COG: COG0612; Pfam: PF00675,PF05193; InterPro: IPR011237.
       0.726
EFK56500.1
Peptidase M16 inactive domain protein; Pfam: PF05193; InterPro: IPR011237.
       0.726
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
   
 0.710
EFK57889.1
Hypothetical protein; COG: COG4635; 1.3.3.4.
     
 0.554
hemB
Porphobilinogen synthase; COG: COG0113; Pfam: PF00490; InterPro: IPR013785; Belongs to the ALAD family.
 
  
 0.501
Your Current Organism:
Sphingobacterium spiritivorum
NCBI taxonomy Id: 525373
Other names: S. spiritivorum ATCC 33861, Sphingobacterium spiritivorum ATCC 33861, Sphingobacterium spiritivorum str. ATCC 33861, Sphingobacterium spiritivorum strain ATCC 33861
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