STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobAuroporphyrinogen-III C-methyltransferase; COG: COG0007; Pfam: PF00590; InterPro: IPR006366. (252 aa)    
Predicted Functional Partners:
cysG
Siroheme synthase domain protein; COG: COG1648; InterPro: IPR006367.
 
 0.999
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.993
cysI
Nitrite/sulfite reductase ferredoxin domain protein; COG: COG0155; Pfam: PF03460,PF01077,PF05168; InterPro: IPR006067.
 
  
 0.993
atpB3
Adenylylsulfate reductase, thioredoxin dependent; Reduction of activated sulfate into sulfite.
 
  
 0.975
cysD
Sulfate adenylyltransferase, small subunit; COG: COG0175; Pfam: PF01507; InterPro: IPR011784.
 
  
 0.956
hemD
uroporphyrinogen-III synthase; Pfam: PF02602.
  
 
 0.954
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.952
hemB
Porphobilinogen synthase; COG: COG0113; Pfam: PF00490; InterPro: IPR013785; Belongs to the ALAD family.
 
 
 0.926
cysN
Sulfate adenylyltransferase, large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
 
  
 0.841
cysC
Putative adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate.
 
  
 0.833
Your Current Organism:
Sphingobacterium spiritivorum
NCBI taxonomy Id: 525373
Other names: S. spiritivorum ATCC 33861, Sphingobacterium spiritivorum ATCC 33861, Sphingobacterium spiritivorum str. ATCC 33861, Sphingobacterium spiritivorum strain ATCC 33861
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