node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFK56530.1 | EFK56532.1 | HMPREF0766_13733 | HMPREF0766_13735 | Tat pathway signal sequence domain protein; COG: COG2008; Pfam: PF01212; InterPro: IPR015421. | Transporter, major facilitator family protein; Pfam: PF07690; InterPro: IPR011701. | 0.492 |
EFK56530.1 | gcvP | HMPREF0766_13733 | HMPREF0766_10881 | Tat pathway signal sequence domain protein; COG: COG2008; Pfam: PF01212; InterPro: IPR015421. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.752 |
EFK56530.1 | gcvT | HMPREF0766_13733 | HMPREF0766_10898 | Tat pathway signal sequence domain protein; COG: COG2008; Pfam: PF01212; InterPro: IPR015421. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.484 |
EFK56530.1 | glyA | HMPREF0766_13733 | HMPREF0766_12244 | Tat pathway signal sequence domain protein; COG: COG2008; Pfam: PF01212; InterPro: IPR015421. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.655 |
EFK56530.1 | ilvA | HMPREF0766_13733 | HMPREF0766_11218 | Tat pathway signal sequence domain protein; COG: COG2008; Pfam: PF01212; InterPro: IPR015421. | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.623 |
EFK56530.1 | kbl | HMPREF0766_13733 | HMPREF0766_10799 | Tat pathway signal sequence domain protein; COG: COG2008; Pfam: PF01212; InterPro: IPR015421. | Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.579 |
EFK56530.1 | sdh | HMPREF0766_13733 | HMPREF0766_11557 | Tat pathway signal sequence domain protein; COG: COG2008; Pfam: PF01212; InterPro: IPR015421. | Oxidoreductase, short chain dehydrogenase/reductase family protein; COG: COG4221; Pfam: PF00106; InterPro: IPR002198; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.592 |
EFK56530.1 | thrC | HMPREF0766_13733 | HMPREF0766_12532 | Tat pathway signal sequence domain protein; COG: COG2008; Pfam: PF01212; InterPro: IPR015421. | Threonine synthase; COG: COG0498; Pfam: PF00291; InterPro: IPR004450. | 0.654 |
EFK56530.1 | ybaO | HMPREF0766_13733 | HMPREF0766_13734 | Tat pathway signal sequence domain protein; COG: COG2008; Pfam: PF01212; InterPro: IPR015421. | Transcriptional regulator, AsnC family; COG: COG1522; Pfam: PF01037; InterPro: IPR000485. | 0.697 |
EFK56532.1 | EFK56530.1 | HMPREF0766_13735 | HMPREF0766_13733 | Transporter, major facilitator family protein; Pfam: PF07690; InterPro: IPR011701. | Tat pathway signal sequence domain protein; COG: COG2008; Pfam: PF01212; InterPro: IPR015421. | 0.492 |
EFK56532.1 | ybaO | HMPREF0766_13735 | HMPREF0766_13734 | Transporter, major facilitator family protein; Pfam: PF07690; InterPro: IPR011701. | Transcriptional regulator, AsnC family; COG: COG1522; Pfam: PF01037; InterPro: IPR000485. | 0.528 |
gcvP | EFK56530.1 | HMPREF0766_10881 | HMPREF0766_13733 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Tat pathway signal sequence domain protein; COG: COG2008; Pfam: PF01212; InterPro: IPR015421. | 0.752 |
gcvP | gcvT | HMPREF0766_10881 | HMPREF0766_10898 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvP | glyA | HMPREF0766_10881 | HMPREF0766_12244 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.998 |
gcvP | ilvA | HMPREF0766_10881 | HMPREF0766_11218 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.449 |
gcvP | kbl | HMPREF0766_10881 | HMPREF0766_10799 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.958 |
gcvP | sdh | HMPREF0766_10881 | HMPREF0766_11557 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Oxidoreductase, short chain dehydrogenase/reductase family protein; COG: COG4221; Pfam: PF00106; InterPro: IPR002198; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.453 |
gcvP | thrC | HMPREF0766_10881 | HMPREF0766_12532 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Threonine synthase; COG: COG0498; Pfam: PF00291; InterPro: IPR004450. | 0.429 |
gcvT | EFK56530.1 | HMPREF0766_10898 | HMPREF0766_13733 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Tat pathway signal sequence domain protein; COG: COG2008; Pfam: PF01212; InterPro: IPR015421. | 0.484 |
gcvT | gcvP | HMPREF0766_10898 | HMPREF0766_10881 | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |