STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (215 aa)    
Predicted Functional Partners:
pyrF
Orotidine 5'-phosphate decarboxylase; COG: COG0284; Pfam: PF00215; InterPro: IPR011995; Belongs to the OMP decarboxylase family. Type 2 subfamily.
 
 
 0.998
pyrD
Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
 
 0.997
carB
Carbamoyl-phosphate synthase, large subunit; COG: COG0458; Pfam: PF00289,PF02786,PF02787; InterPro: IPR006275.
 
 
 0.959
carA
Carbamoyl-phosphate synthase, small subunit; COG: COG0505; Pfam: PF00988,PF00117; InterPro: IPR006274; Belongs to the CarA family.
 
  
 0.955
pyrB
Aspartate carbamoyltransferase; COG: COG0540; Pfam: PF02729,PF00185; InterPro: IPR002082; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
  
 0.951
prs
Ribose-phosphate diphosphokinase; COG: COG0462; Pfam: PF00156; InterPro: IPR005946.
  
 
 0.951
allB
Amidohydrolase family protein; COG: COG0044; Pfam: PF01979.
 
 
 0.920
pyrC
Amidohydrolase family protein; COG: COG0044; Pfam: PF01979; InterPro: IPR004722.
 
 
 0.916
upp
Phosphoribosyl transferase domain protein; COG: COG2065; Pfam: PF00156; InterPro: IPR000836.
  
 
 0.883
pyrR
Phosphoribosyl transferase domain protein; Pfam: PF00156.
  
 
 0.883
Your Current Organism:
Sphingobacterium spiritivorum
NCBI taxonomy Id: 525373
Other names: S. spiritivorum ATCC 33861, Sphingobacterium spiritivorum ATCC 33861, Sphingobacterium spiritivorum str. ATCC 33861, Sphingobacterium spiritivorum strain ATCC 33861
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