STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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folARiboflavin biosynthesis protein RibD C-terminal domain protein; COG: COG0262; Pfam: PF01872. (184 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.921
folC
Bifunctional protein FolC; COG: COG0285; Pfam: PF08245,PF02875; InterPro: IPR001645; Belongs to the folylpolyglutamate synthase family.
     
 0.708
EFK56575.1
Hypothetical protein.
       0.570
tdk
Thymidine kinase; COG: COG1435; Pfam: PF00265; InterPro: IPR001267.
  
 
 0.469
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.469
EFK60060.1
Transcriptional regulator, AraC family; Pfam: PF00165.
  
     0.468
folP
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
    
 0.465
folD
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.455
purD
Phosphoribosylamine--glycine ligase; COG: COG0151; Pfam: PF02844,PF01071,PF02843; InterPro: IPR000115; Belongs to the GARS family.
  
 
 0.443
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG: COG0138; Pfam: PF02142,PF01808; InterPro: IPR002695.
    
 0.443
Your Current Organism:
Sphingobacterium spiritivorum
NCBI taxonomy Id: 525373
Other names: S. spiritivorum ATCC 33861, Sphingobacterium spiritivorum ATCC 33861, Sphingobacterium spiritivorum str. ATCC 33861, Sphingobacterium spiritivorum strain ATCC 33861
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