node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDK56034.1 | SDK77068.1 | SAMN04487971_101361 | SAMN04487971_10339 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.753 |
SDK56034.1 | ilvA | SAMN04487971_101361 | SAMN04487971_107196 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.685 |
SDK56034.1 | ilvE | SAMN04487971_101361 | SAMN04487971_10121 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.902 |
SDK56034.1 | leuA | SAMN04487971_101361 | SAMN04487971_12512 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.875 |
SDK77068.1 | SDK56034.1 | SAMN04487971_10339 | SAMN04487971_101361 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.753 |
SDK77068.1 | SDL41387.1 | SAMN04487971_10339 | SAMN04487971_11060 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dehydratase family protein. | 0.754 |
SDK77068.1 | SDL41418.1 | SAMN04487971_10339 | SAMN04487971_11061 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dehydratase family protein; Belongs to the IlvD/Edd family. | 0.754 |
SDK77068.1 | SDL42545.1 | SAMN04487971_10339 | SAMN04487971_11096 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.759 |
SDK77068.1 | ilvD | SAMN04487971_10339 | SAMN04487971_107101 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.758 |
SDK77068.1 | ilvE | SAMN04487971_10339 | SAMN04487971_10121 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.979 |
SDK77068.1 | leuA | SAMN04487971_10339 | SAMN04487971_12512 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.914 |
SDL10252.1 | SDL28238.1 | SAMN04487971_106110 | SAMN04487971_108121 | O-succinylhomoserine sulfhydrylase. | Homoserine dehydrogenase. | 0.955 |
SDL10252.1 | ilvA | SAMN04487971_106110 | SAMN04487971_107196 | O-succinylhomoserine sulfhydrylase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.928 |
SDL10252.1 | ilvE | SAMN04487971_106110 | SAMN04487971_10121 | O-succinylhomoserine sulfhydrylase. | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.813 |
SDL28238.1 | SDL10252.1 | SAMN04487971_108121 | SAMN04487971_106110 | Homoserine dehydrogenase. | O-succinylhomoserine sulfhydrylase. | 0.955 |
SDL28238.1 | ilvA | SAMN04487971_108121 | SAMN04487971_107196 | Homoserine dehydrogenase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.749 |
SDL28238.1 | ilvE | SAMN04487971_108121 | SAMN04487971_10121 | Homoserine dehydrogenase. | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.923 |
SDL41387.1 | SDK77068.1 | SAMN04487971_11060 | SAMN04487971_10339 | Dehydratase family protein. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.754 |
SDL41387.1 | SDL41418.1 | SAMN04487971_11060 | SAMN04487971_11061 | Dehydratase family protein. | Dehydratase family protein; Belongs to the IlvD/Edd family. | 0.994 |
SDL41387.1 | ilvA | SAMN04487971_11060 | SAMN04487971_107196 | Dehydratase family protein. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.696 |