node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDK48833.1 | SDK91084.1 | SAMN04487971_101157 | SAMN04487971_10465 | Aminomethyltransferase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.906 |
SDK48833.1 | SDL25113.1 | SAMN04487971_101157 | SAMN04487971_10821 | Aminomethyltransferase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.947 |
SDK48833.1 | folD | SAMN04487971_101157 | SAMN04487971_101286 | Aminomethyltransferase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.958 |
SDK48833.1 | glyA | SAMN04487971_101157 | SAMN04487971_10569 | Aminomethyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.996 |
SDK48833.1 | rpsF | SAMN04487971_101157 | SAMN04487971_102128 | Aminomethyltransferase. | SSU ribosomal protein S6P; Binds together with S18 to 16S ribosomal RNA. | 0.544 |
SDK91084.1 | SDK48833.1 | SAMN04487971_10465 | SAMN04487971_101157 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase. | 0.906 |
SDK91084.1 | SDL10252.1 | SAMN04487971_10465 | SAMN04487971_106110 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | O-succinylhomoserine sulfhydrylase. | 0.948 |
SDK91084.1 | SDL25113.1 | SAMN04487971_10465 | SAMN04487971_10821 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
SDK91084.1 | folD | SAMN04487971_10465 | SAMN04487971_101286 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.943 |
SDK91084.1 | glyA | SAMN04487971_10465 | SAMN04487971_10569 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.970 |
SDK91084.1 | metAA | SAMN04487971_10465 | SAMN04487971_103205 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.941 |
SDK91084.1 | metK | SAMN04487971_10465 | SAMN04487971_103236 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.909 |
SDK91084.1 | metN | SAMN04487971_10465 | SAMN04487971_11235 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | D-methionine transport system ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. | 0.853 |
SDK91084.1 | rpsF | SAMN04487971_10465 | SAMN04487971_102128 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | SSU ribosomal protein S6P; Binds together with S18 to 16S ribosomal RNA. | 0.936 |
SDK91084.1 | thyX | SAMN04487971_10465 | SAMN04487971_101107 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.901 |
SDL10252.1 | SDK91084.1 | SAMN04487971_106110 | SAMN04487971_10465 | O-succinylhomoserine sulfhydrylase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.948 |
SDL10252.1 | SDL25113.1 | SAMN04487971_106110 | SAMN04487971_10821 | O-succinylhomoserine sulfhydrylase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.987 |
SDL10252.1 | glyA | SAMN04487971_106110 | SAMN04487971_10569 | O-succinylhomoserine sulfhydrylase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.575 |
SDL10252.1 | metAA | SAMN04487971_106110 | SAMN04487971_103205 | O-succinylhomoserine sulfhydrylase. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.977 |
SDL10252.1 | metK | SAMN04487971_106110 | SAMN04487971_103236 | O-succinylhomoserine sulfhydrylase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.879 |