EV44_g1790 protein (Erysiphe necator) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

EV44_g1790

Putative zinc finger protein. (1148 aa)

Predicted Functional Partners:

EV44_g2546

0.644

EV44_g1175

0.621

EV44_g2770

0.621

EV44_g5308

0.619

EV44_g1250

0.619

EV44_g2981

0.614

EV44_g3703

0.592

EV44_g2340

0.591

EV44_g2060

0.591

EV44_g5895

0.591

Your Current Organism:

Erysiphe necator

NCBI taxonomy Id: 52586
Other names: E. necator, Uncinula necator, grape powdery mildew

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EV44_g1175	EV44_g1250	A0A0B1NYX9	A0A0B1PFF4	Putative ubiquitin-like modifier.	Putative scf complex subunit skp1; Belongs to the SKP1 family.	0.519
EV44_g1175	EV44_g1790	A0A0B1NYX9	A0A0B1PA62	Putative ubiquitin-like modifier.	Putative zinc finger protein.	0.621
EV44_g1175	EV44_g2546	A0A0B1NYX9	A0A0B1P2J4	Putative ubiquitin-like modifier.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.517
EV44_g1175	EV44_g2770	A0A0B1NYX9	A0A0B1P967	Putative ubiquitin-like modifier.	Putative 26s proteasome regulatory subunit.	0.769
EV44_g1175	EV44_g2981	A0A0B1NYX9	A0A0B1P2A6	Putative ubiquitin-like modifier.	Uncharacterized protein.	0.990
EV44_g1175	EV44_g5308	A0A0B1NYX9	A0A0B1PBM2	Putative ubiquitin-like modifier.	Uncharacterized protein.	0.519
EV44_g1250	EV44_g1175	A0A0B1PFF4	A0A0B1NYX9	Putative scf complex subunit skp1; Belongs to the SKP1 family.	Putative ubiquitin-like modifier.	0.519
EV44_g1250	EV44_g1790	A0A0B1PFF4	A0A0B1PA62	Putative scf complex subunit skp1; Belongs to the SKP1 family.	Putative zinc finger protein.	0.619
EV44_g1250	EV44_g2546	A0A0B1PFF4	A0A0B1P2J4	Putative scf complex subunit skp1; Belongs to the SKP1 family.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.646
EV44_g1250	EV44_g2770	A0A0B1PFF4	A0A0B1P967	Putative scf complex subunit skp1; Belongs to the SKP1 family.	Putative 26s proteasome regulatory subunit.	0.843
EV44_g1790	EV44_g1175	A0A0B1PA62	A0A0B1NYX9	Putative zinc finger protein.	Putative ubiquitin-like modifier.	0.621
EV44_g1790	EV44_g1250	A0A0B1PA62	A0A0B1PFF4	Putative zinc finger protein.	Putative scf complex subunit skp1; Belongs to the SKP1 family.	0.619
EV44_g1790	EV44_g2060	A0A0B1PA62	A0A0B1P803	Putative zinc finger protein.	Putative 14-3-3 family protein; Belongs to the 14-3-3 family.	0.591
EV44_g1790	EV44_g2340	A0A0B1PA62	A0A0B1P6A7	Putative zinc finger protein.	Putative 14-3-3 protein; Belongs to the 14-3-3 family.	0.591
EV44_g1790	EV44_g2546	A0A0B1PA62	A0A0B1P2J4	Putative zinc finger protein.	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.	0.644
EV44_g1790	EV44_g2770	A0A0B1PA62	A0A0B1P967	Putative zinc finger protein.	Putative 26s proteasome regulatory subunit.	0.621
EV44_g1790	EV44_g2981	A0A0B1PA62	A0A0B1P2A6	Putative zinc finger protein.	Uncharacterized protein.	0.614
EV44_g1790	EV44_g3703	A0A0B1PA62	A0A0B1P5R9	Putative zinc finger protein.	Putative mhyt domain signaling protein.	0.592
EV44_g1790	EV44_g5308	A0A0B1PA62	A0A0B1PBM2	Putative zinc finger protein.	Uncharacterized protein.	0.619
EV44_g1790	EV44_g5895	A0A0B1PA62	A0A0B1P8E4	Putative zinc finger protein.	Putative 14-3-3 protein.	0.591

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

42

average node degree:

7.64

avg. local clustering coefficient:

0.815

expected number of edges:

14

PPI enrichment p-value:

2.03e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006620

Post-translational protein targeting to endoplasmic reticulum membrane

6 of 16

3.01

6.96

1.02e-13

GO:0090150

Establishment of protein localization to membrane

8 of 128

2.23

5.8

1.02e-13

GO:0033365

Protein localization to organelle

8 of 375

1.77

3.63

5.64e-11

GO:0051205

Protein insertion into membrane

4 of 43

2.41

3.25

5.01e-07

GO:0045048

Protein insertion into ER membrane

2 of 18

2.48

1.32

0.0037

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016887

ATP hydrolysis activity

6 of 674

1.39

1.43

0.00012

GO:0004725

Protein tyrosine phosphatase activity

2 of 33

2.22

1.12

0.0080

GO:0003993

Acid phosphatase activity

2 of 53

2.01

0.92

0.0186

GO:0005524

ATP binding

8 of 3950

0.74

0.56

0.0032

GO:0016787

Hydrolase activity

8 of 4055

0.73

0.55

0.0032

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043529

GET complex

6 of 9

3.26

8.01

1.86e-15

GO:0010287

Plastoglobule

2 of 42

2.11

1.0

0.0134

GO:0009570

Chloroplast stroma

4 of 516

1.33

0.96

0.0044

GO:0009536

Plastid

8 of 2552

0.93

0.88

9.81e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:43140

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane, and Citrate transporter-like domain

9 of 26

2.98

11.13

3.83e-22

CL:43142

Arsenical pump ATPase, ArsA/GET3, and Melanin biosynthesis

7 of 11

3.24

9.54

2.16e-18

CL:43145

Arsenical pump ATPase, ArsA/GET3, and Melanin biosynthesis

3 of 5

3.21

3.2

1.59e-06

CL:26999

Mixed, incl. Blockage of phagosome acidification, and E3 ubiquitin-protein ligase BAH1

2 of 7

2.89

1.39

0.0030

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9609523

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

6 of 27

2.78

6.48

4.14e-13

MAP-9609507

Protein localization

6 of 272

1.78

2.82

1.10e-07

MAP-9637687

Suppression of phagosomal maturation

2 of 2

3.44

2.06

0.00020

MAP-9637628

Modulation by Mtb of host immune system

2 of 2

3.44

2.06

0.00020

MAP-9636467

Blockage of phagosome acidification

2 of 2

3.44

2.06

0.00020

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043529

GET complex

6 of 9

3.26

7.9

3.00e-15

GOCC:0010287

Plastoglobule

2 of 47

2.07

0.82

0.0290

GOCC:0005737

Cytoplasm

11 of 9454

0.5

0.41

0.0013

GOCC:0043227

Membrane-bounded organelle

11 of 10964

0.44

0.34

0.0051

GOCC:0043231

Intracellular membrane-bounded organelle

10 of 10326

0.42

0.3

0.0290

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0067

ATP-binding

6 of 1342

1.09

0.94

0.00086

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02374

Anion-transporting ATPase

4 of 5

3.34

4.73

2.64e-09

PF01656

CobQ/CobB/MinD/ParA nucleotide binding domain

2 of 2

3.44

1.73

0.00079

PF13614

AAA domain

2 of 3

3.26

1.7

0.00088

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR025723

Anion-transporting ATPase-like domain

7 of 7

3.44

9.73

1.56e-18

IPR016300

Arsenical pump ATPase, ArsA/GET3

6 of 6

3.44

8.17

1.27e-15

IPR036196

Phosphotyrosine protein phosphatase I superfamily

2 of 2

3.44

1.65

0.0011

IPR023485

Phosphotyrosine protein phosphatase I

2 of 2

3.44

1.65

0.0011

IPR027417

P-loop containing nucleoside triphosphate hydrolase

7 of 1570

1.09

0.96

0.00060

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00226

Low molecular weight phosphatase family

2 of 2

3.44

1.92

0.00035

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