Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
recD2Helicase, RecD/TraA family; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (715 aa)    
Predicted Functional Partners:
Taci_1693
PFAM: UvrD/REP helicase; KEGG: ade:Adeh_2512 UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily.
  
 
 0.882
Taci_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.839
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.832
Taci_0748
PFAM: UvrD/REP helicase; KEGG: bha:BH0648 ATP-dependent DNA helicase.
  
 
 0.819
Taci_1689
PFAM: metallophosphoesterase; KEGG: mxa:MXAN_4514 metallophosphoesterase.
   
 
 0.795
Taci_1688
PFAM: SMC domain protein; KEGG: mxa:MXAN_4513 hypothetical protein.
   
 
 0.783
Taci_0502
PFAM: protein of unknown function DUF1063; KEGG: dvm:DvMF_1488 protein of unknown function DUF1063; Belongs to the UPF0597 family.
       0.773
Taci_0504
KEGG: oca:OCAR_5226 hypothetical protein.
       0.773
Taci_0651
TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n; nucleic acid binding OB-fold tRNA/helicase-type; KEGG: mxa:MXAN_1071 single-strand binding protein.
   
 
 0.753
Taci_0501
PFAM: Amidohydrolase 3; KEGG: bsu:BSU29550 hypothetical protein.
       0.704
Your Current Organism:
Thermanaerovibrio acidaminovorans
NCBI taxonomy Id: 525903
Other names: T. acidaminovorans DSM 6589, Thermanaerovibrio acidaminovorans DSM 6589, Thermanaerovibrio acidaminovorans str. DSM 6589, Thermanaerovibrio acidaminovorans strain DSM 6589
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