Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Taci_1493PFAM: SMC domain protein; KEGG: afr:AFE_3193 PHP domain protein. (892 aa)    
Predicted Functional Partners:
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.799
Taci_0776
Chromosome segregation and condensation protein ScpA; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
  
 
 0.794
Taci_1492
PFAM: helicase domain protein; SNF2-related protein; type III restriction protein res subunit; SMART: helicase domain protein; DEAD-like helicase; KEGG: dno:DNO_0177 DEAD helicase domain-containing protein VrlO.
   
 0.741
Taci_1494
PFAM: DNA methylase N-4/N-6 domain protein; KEGG: dno:DNO_0180 S-adenosyl-L-methionine- dependent methyltransferases family protein VrlL.
       0.697
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
 
 0.649
Taci_1489
Hypothetical protein.
       0.625
Taci_1490
KEGG: dol:Dole_0433 hypothetical protein.
       0.625
Taci_1491
PFAM: PglZ domain protein; KEGG: dol:Dole_0434 alkaline phosphatase domain- containing protein.
       0.625
Taci_1495
PFAM: S23 ribosomal protein; KEGG: gur:Gura_0834 S23 ribosomal protein.
  
  
 0.613
Taci_1498
TIGRFAM: DNA binding domain protein, excisionase family; PFAM: regulatory protein MerR; Prophage CP4-57 regulatory; KEGG: sat:SYN_01853 MerR family regulatory protein.
 
     0.584
Your Current Organism:
Thermanaerovibrio acidaminovorans
NCBI taxonomy Id: 525903
Other names: T. acidaminovorans DSM 6589, Thermanaerovibrio acidaminovorans DSM 6589, Thermanaerovibrio acidaminovorans str. DSM 6589, Thermanaerovibrio acidaminovorans strain DSM 6589
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