STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (303 aa)    
Predicted Functional Partners:
lipB
Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
 
 0.998
Tter_0676
PFAM: biotin/lipoate A/B protein ligase; KEGG: bha:BH2812 lipoate protein ligase.
 
 
 0.934
Tter_0095
PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain- containing protein; E3 binding domain protein; KEGG: bha:BH2761 branched-chain alpha-keto acid dehydrogenase subunit E2.
 
  
 0.805
Tter_0093
3-methyl-2-oxobutanoate dehydrogenase (2- methylpropanoyl-transferring); PFAM: dehydrogenase E1 component; KEGG: bce:BC4159 2-oxoisovalerate dehydrogenase alpha subunit.
     
 0.673
Tter_0094
PFAM: Transketolase central region; Transketolase domain protein; KEGG: bha:BH2762 branched-chain alpha-keto acid dehydrogenase E1.
  
  
 0.670
Tter_0092
Dihydrolipoyllysine-residue succinyltransferase; PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain- containing protein; E3 binding domain protein; KEGG: mxa:MXAN_2668 pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase.
 
  
 0.625
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
   
 0.614
pdhA
Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
 0.496
Tter_0091
Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
  
  
 0.491
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.430
Your Current Organism:
Thermobaculum terrenum
NCBI taxonomy Id: 525904
Other names: T. terrenum ATCC BAA-798, Thermobaculum terrenum ATCC BAA-798, Thermobaculum terrenum YNP1, Thermobaculum terrenum str. ATCC BAA-798, Thermobaculum terrenum strain ATCC BAA-798
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