STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (930 aa)    
Predicted Functional Partners:
Tter_0993
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
 0.996
Tter_0697
PFAM: metallophosphoesterase; KEGG: pca:Pcar_1060 DNA repair exonuclease.
  
 0.983
Tter_1873
PFAM: metallophosphoesterase; KEGG: gsu:GSU1724 nuclease SbcCD, D subunit, putative.
  
 0.983
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.967
dinG
DNA polymerase III, epsilon subunit; 3'-5' exonuclease.
  
 0.958
Tter_0696
PFAM: SMC domain protein; KEGG: sun:SUN_0726 DNA double-strand break repair protein.
  
 0.957
Tter_1874
PFAM: SMC domain protein; KEGG: SMC domain protein.
  
 0.957
Tter_1920
KEGG: nmu:Nmul_A2304 ATP-dependent DNA helicase RecQ; TIGRFAM: ATP-dependent DNA helicase, RecQ family; PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: helicase domain protein; DEAD-like helicase.
  
 0.951
Tter_2648
PFAM: helicase domain protein; type III restriction protein res subunit; SMART: helicase domain protein; DEAD-like helicase; KEGG: mgm:Mmc1_2016 helicase domain protein.
  
 0.947
lig
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
  
 0.946
Your Current Organism:
Thermobaculum terrenum
NCBI taxonomy Id: 525904
Other names: T. terrenum ATCC BAA-798, Thermobaculum terrenum ATCC BAA-798, Thermobaculum terrenum YNP1, Thermobaculum terrenum str. ATCC BAA-798, Thermobaculum terrenum strain ATCC BAA-798
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