STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (300 aa)    
Predicted Functional Partners:
Tter_1341
Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 0.999
Tter_1340
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: gur:Gura_0347 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.998
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.994
Tter_0581
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: sat:SYN_02272 uroporphyrin-III C- methyltransferase; Belongs to the precorrin methyltransferase family.
  
 0.990
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.928
Tter_0580
TIGRFAM: siroheme synthase; KEGG: cja:CJA_2551 siroheme synthase.
  
 0.907
hemL
TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: dal:Dalk_2855 glutamate-1-semialdehyde-2,1- aminomutase.
  
 0.904
Tter_1965
PFAM: aminotransferase class-III; KEGG: dal:Dalk_2855 glutamate-1-semialdehyde-2,1- aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.862
Tter_0352
PFAM: aminotransferase class-III; KEGG: sil:SPOA0312 glutamate-1-semialdehyde 2,1- aminomutase, putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.811
Tter_2260
PFAM: Uroporphyrinogen decarboxylase (URO-D); KEGG: reu:Reut_B5441 uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family.
  
 
 0.634
Your Current Organism:
Thermobaculum terrenum
NCBI taxonomy Id: 525904
Other names: T. terrenum ATCC BAA-798, Thermobaculum terrenum ATCC BAA-798, Thermobaculum terrenum YNP1, Thermobaculum terrenum str. ATCC BAA-798, Thermobaculum terrenum strain ATCC BAA-798
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