STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ligDNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (583 aa)    
Predicted Functional Partners:
Tter_0993
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.994
Tter_1075
PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; DNA polymerase X; Helix-hairpin-helix DNA-binding class 1; KEGG: sat:SYN_00286 DNA polymerase IV.
  
 0.964
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.929
Tter_2648
PFAM: helicase domain protein; type III restriction protein res subunit; SMART: helicase domain protein; DEAD-like helicase; KEGG: mgm:Mmc1_2016 helicase domain protein.
  
 0.705
Tter_1401
PFAM: peptidase M29 aminopeptidase II; KEGG: gur:Gura_1909 peptidase M29, aminopeptidase II.
       0.689
Tter_0145
TIGRFAM: D,D-heptose 1,7-bisphosphate phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: Polynucleotide kinase 3 phosphatase central region; Haloacid dehalogenase domain protein hydrolase; KEGG: D,D-heptose 1,7-bisphosphate phosphatase; K03273 D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase.
   
 0.667
dinG
DNA polymerase III, epsilon subunit; 3'-5' exonuclease.
   
 
 0.662
Tter_0696
PFAM: SMC domain protein; KEGG: sun:SUN_0726 DNA double-strand break repair protein.
   
 0.566
Tter_1874
PFAM: SMC domain protein; KEGG: SMC domain protein.
   
 0.566
Tter_0697
PFAM: metallophosphoesterase; KEGG: pca:Pcar_1060 DNA repair exonuclease.
  
 0.563
Your Current Organism:
Thermobaculum terrenum
NCBI taxonomy Id: 525904
Other names: T. terrenum ATCC BAA-798, Thermobaculum terrenum ATCC BAA-798, Thermobaculum terrenum YNP1, Thermobaculum terrenum str. ATCC BAA-798, Thermobaculum terrenum strain ATCC BAA-798
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