Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
nfoApurinic endonuclease Apn1; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (296 aa)    
Predicted Functional Partners:
Tter_0762
PFAM: HhH-GPD family protein; helix-hairpin-helix motif; SMART: HhH-GPD family protein; KEGG: mrd:Mrad2831_5333 helix-hairpin-helix DNA- binding motif-containing protein.
  
 
 0.850
Tter_1686
Hypothetical protein; KEGG: pnu:Pnuc_0979 putative ribonuclease BN.
       0.773
Tter_0241
PFAM: periplasmic binding protein; KEGG: pzu:PHZ_c1916 probable periplasmic substrate- binding protein.
 
      0.692
Tter_1687
KEGG: scl:sce5102 hypothetical protein.
       0.655
Tter_2035
PFAM: glycoside hydrolase 15-related; KEGG: noc:Noc_1617 glycoside hydrolase.
 
      0.616
Tter_0145
TIGRFAM: D,D-heptose 1,7-bisphosphate phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: Polynucleotide kinase 3 phosphatase central region; Haloacid dehalogenase domain protein hydrolase; KEGG: D,D-heptose 1,7-bisphosphate phosphatase; K03273 D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase.
   
 
 0.580
Tter_1684
PFAM: Serine/threonine protein kinase-related; tyrosine protein kinase; protein of unknown function RIO1; Fibronectin type III domain protein; SMART: serine/threonine protein kinase; tyrosine protein kinase; Fibronectin type III domain protein; KEGG: bha:BH2504 serine/threonine protein kinase.
     
 0.579
dinG
DNA polymerase III, epsilon subunit; 3'-5' exonuclease.
  
  
 0.554
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.547
Tter_0340
Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
  
  
 0.524
Your Current Organism:
Thermobaculum terrenum
NCBI taxonomy Id: 525904
Other names: T. terrenum ATCC BAA-798, Thermobaculum terrenum ATCC BAA-798, Thermobaculum terrenum YNP1, Thermobaculum terrenum str. ATCC BAA-798, Thermobaculum terrenum strain ATCC BAA-798
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.