Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (320 aa)    
Predicted Functional Partners:
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.979
ctaB
Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
  
 
 0.946
Tter_1872
KEGG: sus:Acid_2208 magnesium protoporphyrin chelatase, putative.
  
 
 0.919
Tter_2554
Flavodoxin-like protein; KEGG: sbc:SbBS512_E4320 protoporphyrinogen oxidase.
    
 0.913
Tter_2562
Flavodoxin-like protein; KEGG: pmu:PM1499 protoporphyrinogen oxidase.
    
 0.913
Tter_0254
PFAM: Rubrerythrin; Ferritin Dps family protein; KEGG: nis:NIS_1151 bacterioferritin.
     
  0.900
Tter_0082
PFAM: amine oxidase; KEGG: psp:PSPPH_0963 hypothetical protein.
  
 
 0.819
Tter_2033
PFAM: Chlorite dismutase; KEGG: bcy:Bcer98_3909 putative heme peroxidase.
 
  
 0.782
Tter_2260
PFAM: Uroporphyrinogen decarboxylase (URO-D); KEGG: reu:Reut_B5441 uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family.
  
  
 0.630
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.623
Your Current Organism:
Thermobaculum terrenum
NCBI taxonomy Id: 525904
Other names: T. terrenum ATCC BAA-798, Thermobaculum terrenum ATCC BAA-798, Thermobaculum terrenum YNP1, Thermobaculum terrenum str. ATCC BAA-798, Thermobaculum terrenum strain ATCC BAA-798
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