Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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Tter_2675PFAM: thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; thiamine pyrophosphate protein TPP binding domain protein; KEGG: vei:Veis_4212 thiamine pyrophosphate enzyme TPP binding domain protein; Belongs to the TPP enzyme family. (550 aa)    
Predicted Functional Partners:
Tter_2674
PFAM: cyclase family protein; KEGG: plu:plu1439 hypothetical protein.
 
     0.939
Tter_0187
TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: sfu:Sfum_3022 acetolactate synthase, small subunit.
 
 
 0.929
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.741
ilvD
KEGG: sus:Acid_0606 dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.725
Tter_1958
PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: sus:Acid_5866 dihydroxyacid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.665
Tter_0186
TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein TPP binding domain protein; thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; KEGG: scl:sce3730 acetolactate synthase.
  
  
 
0.663
Tter_1524
PFAM: thiamine pyrophosphate protein central region; thiamine pyrophosphate protein domain protein TPP- binding; thiamine pyrophosphate protein TPP binding domain protein; KEGG: sus:Acid_1483 thiamine pyrophosphate binding domain-containing protein; Belongs to the TPP enzyme family.
  
  
 
0.577
Tter_2673
PFAM: ABC transporter related; LytTr DNA-binding region; SMART: AAA ATPase; KEGG: bce:BC5286 transcriptional regulator.
     
 0.554
Tter_0474
PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; glutamate synthase; glutamine amidotransferase class-II; KEGG: afw:Anae109_0854 glutamate synthase (ferredoxin).
  
  
 0.547
Tter_0334
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: glo:Glov_1076 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein.
  
  
 0.519
Your Current Organism:
Thermobaculum terrenum
NCBI taxonomy Id: 525904
Other names: T. terrenum ATCC BAA-798, Thermobaculum terrenum ATCC BAA-798, Thermobaculum terrenum YNP1, Thermobaculum terrenum str. ATCC BAA-798, Thermobaculum terrenum strain ATCC BAA-798
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