STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Afer_0033Transcriptional regulator, XRE family; PFAM: DNA polymerase beta domain protein region; helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; KEGG: cmi:CMM_2452 Cro/CI family transcriptional regulator/nucleotidyltransferase. (169 aa)    
Predicted Functional Partners:
Afer_0034
PFAM: protein of unknown function DUF86; KEGG: tel:tll2231 hypothetical protein.
 
  
 0.964
Afer_1341
PFAM: protein of unknown function DUF86; KEGG: mla:Mlab_0885 hypothetical protein.
 
  
 0.850
Afer_1342
PFAM: DNA polymerase beta domain protein region; KEGG: rca:Rcas_2416 DNA polymerase beta subunit.
  
     0.773
Afer_0652
TIGRFAM: competence/damage-inducible protein CinA; PFAM: CinA domain protein; molybdopterin binding domain; KEGG: fal:FRAAL5732 competence-inducible (CinA- like) protein; Belongs to the CinA family.
       0.628
Afer_1988
PFAM: ferredoxin-dependent glutamate synthase; glutamate synthase alpha subunit domain protein; glutamate synthase; glutamine amidotransferase class-II; KEGG: ace:Acel_1078 glutamate synthase (NADH) large subunit.
       0.622
Afer_0459
TIGRFAM: IMP dehydrogenase family protein; PFAM: IMP dehydrogenase/GMP reductase; KEGG: rxy:Rxyl_0815 inositol-5-monophosphate dehydrogenase.
     
 0.561
ispF
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). Belongs to the IspF family. In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
       0.535
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.534
Afer_1495
PFAM: Cys/Met metabolism pyridoxal-phosphate- dependent protein; KEGG: kra:Krad_1362 Cys/Met metabolism pyridoxal- phosphate-dependent protein.
  
  
 0.497
Afer_1940
KEGG: ace:Acel_2052 cysteinyl-tRNA synthetase-like.
       0.477
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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