Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Afer_0104TIGRFAM: methylmalonyl-CoA epimerase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: pho:PH0272 hypothetical protein. (137 aa)    
Predicted Functional Partners:
Afer_0318
PFAM: cobalamin B12-binding domain protein; KEGG: sgr:SGR_2730 putative isobutyryl-CoA mutase, chain B.
  
 0.994
Afer_0223
KEGG: saq:Sare_4003 methylmalonyl-CoA mutase, large subunit; TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase; cobalamin B12- binding domain protein.
 
  
 0.966
Afer_0726
methylmalonyl-CoA mutase, large subunit; KEGG: rxy:Rxyl_1283 methylmalonyl-CoA mutase; TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase.
 
  
 0.959
Afer_1791
methylmalonyl-CoA mutase, large subunit; KEGG: ace:Acel_0674 methylmalonyl-CoA mutase; TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase.
 
  
 0.952
Afer_0231
PFAM: carboxyl transferase; KEGG: rca:Rcas_4102 carboxyl transferase.
 
 
 0.940
Afer_0582
PFAM: carboxyl transferase; KEGG: saq:Sare_0802 carboxyl transferase.
 
 
 0.932
Afer_1780
TIGRFAM: LAO/AO transport system ATPase; PFAM: ArgK protein; KEGG: saq:Sare_3990 LAO/AO transport system ATPase.
  
 0.929
Afer_0730
PFAM: Carbamoyl-phosphate synthase L chain ATP- binding; biotin carboxylase domain protein; biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: kra:Krad_3912 carbamoyl-phosphate synthase L chain ATP-binding.
  
 
 0.907
Afer_0105
TIGRFAM: crotonyl-CoA reductase; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: stp:Strop_3612 crotonyl-CoA reductase.
  
 
 0.843
nuoI
NADH-quinone oxidoreductase, chain I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
  
  
 0.664
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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