Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Afer_0201Histidine kinase; KEGG: tfu:Tfu_2909 sensor histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein. (347 aa)    
Predicted Functional Partners:
Afer_0200
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: mab:MAB_4047c sensory transduction protein RegX3.
 0.999
Afer_0558
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: kra:Krad_3036 two component transcriptional regulator.
 
 0.978
Afer_1175
Osmosensitive K channel signal transduction histidine kinase, sensor subunit KdpD; PFAM: Osmosensitive K channel His kinase sensor; UspA domain protein; KEGG: nfa:nfa15690 putative two-component system sensor kinase.
  
 
 0.911
Afer_0703
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: rha:RHA1_ro08012 response regulator, two- component system.
 
 0.878
Afer_1099
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: fre:Franean1_6145 two component transcriptional regulator.
 
 0.862
Afer_1576
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: hau:Haur_2262 two component transcriptional regulator.
 
 0.856
Afer_1173
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: smd:Smed_5362 two component transcriptional regulator, winged helix family.
 
 
 0.842
Afer_0199
Ferric uptake regulator, Fur family; PFAM: ferric-uptake regulator; KEGG: fra:Francci3_2661 ferric uptake regulator family protein; Belongs to the Fur family.
     
 0.812
Afer_0241
Putative two component transcriptional regulator, winged helix family; PFAM: transcriptional regulator domain protein; KEGG: sma:SAV_4042 two-component system response regulator.
 
 
 0.770
Afer_0217
PFAM: response regulator receiver; SMART: response regulator receiver; KEGG: kra:Krad_0325 response regulator receiver protein.
 
 
 
 0.596
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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