Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Afer_0234Protein of unknown function DUF59; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (368 aa)    
Predicted Functional Partners:
Afer_1089
PFAM: Beta-ketoacyl synthase; KEGG: drm:Dred_2070 beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 
 
    0.890
Afer_0235
PFAM: NUDIX hydrolase; KEGG: maq:Maqu_3801 beta-lactamase domain- containing protein.
       0.773
miaB
RNA modification enzyme, MiaB family; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
  
   
 0.664
Afer_1123
PFAM: Nucleotidyl transferase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; transferase hexapeptide repeat containing protein; KEGG: tfu:Tfu_1394 mannose-1-phosphate guanylyltransferase.
  
  
 0.518
Afer_0236
PFAM: response regulator receiver; SMART: response regulator receiver; KEGG: bur:Bcep18194_B3050 two component transcriptional regulator.
   
   0.512
Afer_0237
PFAM: Anion-transporting ATPase; KEGG: rha:RHA1_ro04317 arsenate (2+)-transporting ATPase.
       0.492
Afer_0238
PFAM: Anion-transporting ATPase; KEGG: ank:AnaeK_0988 chromosome partitioning-like ATPase.
       0.492
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
   
 
 0.411
Afer_0369
NADH-quinone oxidoreductase, chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family.
    
 0.410
nuoI
NADH-quinone oxidoreductase, chain I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
  
 
 0.409
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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