STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Afer_0250Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (291 aa)    
Predicted Functional Partners:
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.999
Afer_0251
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: sus:Acid_3181 uroporphyrinogen-III C- methyltransferase / uroporphyrinogen-III synthase; Belongs to the precorrin methyltransferase family.
 0.999
Afer_0252
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: krh:KRH_08550 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.999
hemL
TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: dol:Dole_1545 glutamate-1-semialdehyde-2,1- aminomutase.
  
 0.988
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.960
Afer_0802
TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; cobalamin (vitamin B12) biosynthesis CbiG protein; KEGG: stp:Strop_2520 precorrin-3B C17- methyltransferase.
     
 0.769
Afer_1983
PFAM: aminotransferase class-III; KEGG: nca:Noca_3921 aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.756
Afer_0817
KEGG: nfa:nfa40830 putative magnesium chelatase subunit; PFAM: ATPase associated with various cellular activities AAA_5; AAA ATPase central domain protein; von Willebrand factor type A; magnesium chelatase ChlI subunit; SMART: von Willebrand factor type A; AAA ATPase.
  
  
 0.735
Afer_0808
TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; protein-L- isoaspartate(D-aspartate) O-methyltransferase; KEGG: syx:SynWH7803_1707 precorrin-6Y methylase.
     
 0.725
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
  
  
 0.674
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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