STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Afer_0273TIGRFAM: agmatinase; PFAM: Arginase/agmatinase/formiminoglutamase; KEGG: nca:Noca_3382 agmatinase; Belongs to the arginase family. (317 aa)    
Predicted Functional Partners:
Afer_1190
PFAM: aminotransferase class-III; KEGG: sen:SACE_3329 adenosylmethionine-8-amino-7- oxononanoate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
   
 
  0.902
Afer_0329
PFAM: Formiminotransferase domain protein; KEGG: sat:SYN_00461 glutamate formiminotransferase.
  
    0.786
Afer_1378
PFAM: Aldehyde Dehydrogenase; Proline dehydrogenase; KEGG: ote:Oter_0715 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
  
 
 0.761
hutH
KEGG: eba:ebA5742 histidine ammonia-lyase; TIGRFAM: histidine ammonia-lyase; PFAM: phenylalanine/histidine ammonia-lyase.
  
  
 0.716
Afer_0274
Transcriptional regulator, XRE family; PFAM: Cupin 2 conserved barrel domain protein; helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; KEGG: art:Arth_0847 transcriptional regulator, XRE family with cupin sensor.
 
   
 0.661
Afer_1662
PFAM: aminotransferase class-III; KEGG: art:Arth_1499 acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.622
Afer_1415
Imidazolonepropionase; KEGG: mmr:Mmar10_1604 imidazolonepropionase; TIGRFAM: imidazolonepropionase; PFAM: amidohydrolase; Amidohydrolase 3.
  
  
 0.604
nadE
NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 0.581
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
       0.562
Afer_0723
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
  
 0.545
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.