Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Afer_0287PFAM: Negative transcriptional regulator; KEGG: sen:SACE_2130 hypothetical protein. (231 aa)    
Predicted Functional Partners:
secE
Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
      
 0.629
secY
Preprotein translocase, SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
      
 0.629
dxs
Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
      
 0.627
rpsD
Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
      
 0.621
Afer_1844
PFAM: AAA ATPase central domain protein; peptidase M41; SMART: AAA ATPase; KEGG: fre:Franean1_1258 ATPase central domain- containing protein; Belongs to the AAA ATPase family.
  
     0.566
Afer_1062
PFAM: major facilitator superfamily MFS_1; KEGG: sgr:SGR_3045 major facilitator superfamily permease.
  
     0.548
Afer_0288
KEGG: hypothetical protein.
       0.496
Afer_1520
PFAM: extracellular solute-binding protein family 5; KEGG: saq:Sare_4778 extracellular solute-binding protein.
  
     0.480
Afer_0229
PFAM: protein of unknown function DUF6 transmembrane; KEGG: sma:SAV_7066 integral membrane protein.
 
     0.475
Afer_1144
PFAM: extracellular solute-binding protein family 5; KEGG: saq:Sare_2145 extracellular solute-binding protein.
  
     0.464
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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