Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Afer_0308KEGG: mav:MAV_4571 metal ion transporter, nramp family protein. (448 aa)    
Predicted Functional Partners:
valS
aminoacyl-tRNA synthetase class Ia; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner.
       0.689
Afer_0475
PFAM: MgtE intracellular region; CBS domain containing protein; SMART: CBS domain containing protein; KEGG: mav:MAV_2122 MgtE intracellular domain family protein.
 
  
 0.523
Afer_0296
PFAM: protein of unknown function DUF74; KEGG: afe:Lferr_1683 hypothetical protein.
  
     0.483
cysS
KEGG: hha:Hhal_0107 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia; Cysteinyl-tRNA synthetase class Ia DALR; Belongs to the class-I aminoacyl-tRNA synthetase family.
       0.478
Afer_1071
PFAM: Peptidase S53 propeptide; KEGG: bph:Bphy_5054 peptidase S53 propeptide.
  
     0.455
Afer_0781
KEGG: acr:Acry_2205 extracellular ligand-binding receptor.
 
     0.439
Afer_0858
TIGRFAM: cation diffusion facilitator family transporter; PFAM: cation efflux protein; KEGG: gsu:GSU0487 cation efflux family protein.
 
 
 
 0.416
Afer_0291
TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase-associated domain protein; Haloacid dehalogenase domain protein hydrolase; cation transporting ATPase domain protein; KEGG: afe:Lferr_2687 ATPase, P-type (transporting), HAD superfamily, subfamily IC.
   
 0.401
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.