Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (322 aa)    
Predicted Functional Partners:
Afer_1123
PFAM: Nucleotidyl transferase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; transferase hexapeptide repeat containing protein; KEGG: tfu:Tfu_1394 mannose-1-phosphate guanylyltransferase.
  
 
 0.933
Afer_0745
PFAM: NAD-dependent epimerase/dehydratase; dTDP-4- dehydrorhamnose reductase; KEGG: afe:Lferr_2889 NAD-dependent epimerase/dehydratase.
  
  
 
0.924
Afer_0738
PFAM: Nucleotidyl transferase; KEGG: rxy:Rxyl_1624 nucleotidyl transferase.
    
 0.905
Afer_0333
PFAM: cytochrome c-type biogenesis protein CcmB; ABC-2 type transporter; KEGG: nca:Noca_1953 cytochrome c-type biogenesis protein CcmB.
       0.809
Afer_0334
PFAM: cytochrome c assembly protein; KEGG: nca:Noca_1955 cytochrome c assembly protein.
       0.809
Afer_0332
Heme exporter protein CcmA; KEGG: nca:Noca_1952 ABC transporter related; TIGRFAM: heme exporter protein CcmA; PFAM: ABC transporter related; SMART: AAA ATPase.
       0.779
rplD
Ribosomal protein L4/L1e; Forms part of the polypeptide exit tunnel.
 
      0.659
Afer_0336
CcmE/CycJ protein; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
     
 0.561
Afer_0330
PFAM: regulatory protein TetR; KEGG: rsa:RSal33209_1214 TetR family transcriptional regulator.
       0.534
Afer_0337
PFAM: cytochrome c assembly protein; KEGG: nca:Noca_1958 cytochrome c assembly protein.
       0.529
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.