STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Afer_0475PFAM: MgtE intracellular region; CBS domain containing protein; SMART: CBS domain containing protein; KEGG: mav:MAV_2122 MgtE intracellular domain family protein. (413 aa)    
Predicted Functional Partners:
Afer_0474
PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; KEGG: dge:Dgeo_2010 PHP-like protein.
       0.673
Afer_0472
PFAM: peptidase U62 modulator of DNA gyrase; KEGG: hmo:HM1_0268 modulator of DNA gyrase, putative.
       0.664
Afer_0473
PFAM: peptidase U62 modulator of DNA gyrase; KEGG: pth:PTH_1159 Zn-dependent protease.
       0.664
Afer_0476
KEGG: ace:Acel_0596 natural resistance-associated macrophage protein.
  
 0.637
ispF
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). Belongs to the IspF family. In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
       0.558
Afer_0308
KEGG: mav:MAV_4571 metal ion transporter, nramp family protein.
  
 0.542
lipB
Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives; Belongs to the LipB family.
  
    0.501
Afer_0469
PFAM: Squalene/phytoene synthase; KEGG: saq:Sare_4931 squalene/phytoene synthase.
       0.464
Afer_0470
TIGRFAM: phytoene desaturase; PFAM: amine oxidase; FAD dependent oxidoreductase; KEGG: nfa:nfa43990 putative phytoene desaturase.
       0.464
Afer_0471
PFAM: Polyprenyl synthetase; KEGG: saq:Sare_3478 polyprenyl synthetase; Belongs to the FPP/GGPP synthase family.
       0.464
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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