Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
Afer_0476KEGG: ace:Acel_0596 natural resistance-associated macrophage protein. (527 aa)    
Predicted Functional Partners:
Afer_0475
PFAM: MgtE intracellular region; CBS domain containing protein; SMART: CBS domain containing protein; KEGG: mav:MAV_2122 MgtE intracellular domain family protein.
 
  
 0.622
Afer_1071
PFAM: Peptidase S53 propeptide; KEGG: bph:Bphy_5054 peptidase S53 propeptide.
  
     0.606
Afer_0296
PFAM: protein of unknown function DUF74; KEGG: afe:Lferr_1683 hypothetical protein.
  
     0.595
Afer_0521
PFAM: phosphoesterase; KEGG: sai:Saci_1769 membrane associated phosphoesterase.
  
   
 0.484
Afer_0081
PFAM: Peptidase S53 propeptide; KEGG: cac:CAC0625 periplasmic aspartyl protease.
  
     0.456
Afer_0477
PFAM: Methyltransferase type 11; methyltransferase small; Methyltransferase type 12; KEGG: hsl:OE2833R hypothetical protein.
       0.456
Afer_0196
PFAM: Peptidase S53 propeptide; KEGG: cac:CAC0625 periplasmic aspartyl protease.
  
     0.454
Afer_0291
TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase-associated domain protein; Haloacid dehalogenase domain protein hydrolase; cation transporting ATPase domain protein; KEGG: afe:Lferr_2687 ATPase, P-type (transporting), HAD superfamily, subfamily IC.
   
 0.401
Afer_1523
PFAM: Cytochrome b/b6 domain; KEGG: ace:Acel_1781 hypothetical protein.
  
     0.400
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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