Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Afer_0490PFAM: Methyltransferase type 11; Methionine biosynthesis MetW protein; Methyltransferase type 12; KEGG: tfu:Tfu_0572 hypothetical protein. (222 aa)    
Predicted Functional Partners:
Afer_0491
KEGG: nfa:nfa25760 hypothetical protein.
 
    0.958
Afer_0489
PFAM: glycosyl transferase group 1; KEGG: sgr:SGR_5187 putative glycosyl transferase.
 
     0.946
Afer_0492
KEGG: sgr:SGR_5196 hypothetical protein.
 
  
 0.795
Afer_0814
PFAM: monooxygenase FAD-binding; FAD dependent oxidoreductase; KEGG: sen:SACE_3057 pentachlorophenol monooxygenase.
  
 0.774
Afer_1168
PFAM: Methyltransferase type 11; UbiE/COQ5 methyltransferase; Methyltransferase type 12; KEGG: mav:MAV_0854 methyltransferase-UbiE family protein.
 
 
 
 0.581
Afer_0488
TIGRFAM: regulatory protein, FmdB family; KEGG: kra:Krad_3694 FmdB family regulatory protein.
       0.512
Afer_0817
KEGG: nfa:nfa40830 putative magnesium chelatase subunit; PFAM: ATPase associated with various cellular activities AAA_5; AAA ATPase central domain protein; von Willebrand factor type A; magnesium chelatase ChlI subunit; SMART: von Willebrand factor type A; AAA ATPase.
  
 
 0.503
ispF
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). Belongs to the IspF family. In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
  
 
 0.469
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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