Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Afer_0493PFAM: Peptidase M1 membrane alanine aminopeptidase; KEGG: ank:AnaeK_2441 peptidase M1 membrane alanine aminopeptidase. (852 aa)    
Predicted Functional Partners:
Afer_0492
KEGG: sgr:SGR_5196 hypothetical protein.
     
 0.786
Afer_0494
PFAM: PfkB domain protein; KEGG: rru:Rru_A0149 PfkB; Belongs to the carbohydrate kinase PfkB family.
 
 
   0.656
Afer_1732
TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Transketolase central region; dehydrogenase E1 component; catalytic domain of components of various dehydrogenase complexes; KEGG: ace:Acel_0586 alpha-ketoglutarate decarboxylase.
   
   0.641
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
 0.555
Afer_0811
Endothelin-converting enzyme 1; PFAM: peptidase M13; peptidase M13 neprilysin; KEGG: lxx:Lxx01010 metallopeptidase.
 
   
 0.531
fusA
Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...]
   
 
 0.499
Afer_1226
Small GTP-binding protein; KEGG: rha:RHA1_ro05886 elongation factor EF2; TIGRFAM: small GTP-binding protein; PFAM: elongation factor G domain IV; elongation factor G domain protein; Miro domain protein; GTP-binding protein HSR1-related; protein synthesis factor GTP- binding; SMART: AAA ATPase.
   
 
 0.499
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.468
Afer_0286
PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; type III restriction protein res subunit; SMART: DEAD-like helicases; helicase domain protein; KEGG: pac:PPA1787 ATP-dependent RNA helicase.
  
 
 0.467
Afer_0298
PFAM: NLP/P60 protein; KEGG: sgr:SGR_2734 NLP/P60 family secreted protein.
  
  
 0.455
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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