STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Afer_0494PFAM: PfkB domain protein; KEGG: rru:Rru_A0149 PfkB; Belongs to the carbohydrate kinase PfkB family. (360 aa)    
Predicted Functional Partners:
Afer_0493
PFAM: Peptidase M1 membrane alanine aminopeptidase; KEGG: ank:AnaeK_2441 peptidase M1 membrane alanine aminopeptidase.
 
 
   0.656
hisA
PFAM: histidine biosynthesis protein; KEGG: mta:Moth_2032 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4- carboxamide isomerase.
  
    0.643
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.588
Afer_0492
KEGG: sgr:SGR_5196 hypothetical protein.
       0.559
Afer_0994
PFAM: periplasmic binding protein/LacI transcriptional regulator; KEGG: acr:Acry_1366 periplasmic binding protein/LacI transcriptional regulator.
 
  
 0.509
Afer_0166
TIGRFAM: transketolase; fructose-1,6- bisphosphatase, class II; PFAM: GlpX family protein; Transketolase domain protein; Transketolase central region; KEGG: ttj:TTHA0108 transketolase; Belongs to the transketolase family.
  
 
 0.499
Afer_0993
Monosaccharide-transporting ATPase; PFAM: inner-membrane translocator; KEGG: rxy:Rxyl_0947 inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family.
 
  
 0.447
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
  
  
 0.422
rpoB
DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 
 0.400
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.