STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Afer_0559PFAM: PDZ/DHR/GLGF domain protein; peptidase S1 and S6 chymotrypsin/Hap; SMART: PDZ/DHR/GLGF domain protein; KEGG: ace:Acel_1716 peptidase S1 and S6, chymotrypsin/Hap. (487 aa)    
Predicted Functional Partners:
arc
AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
    
 0.894
Afer_1990
PFAM: Colicin V production protein; peptidase S1 and S6 chymotrypsin/Hap; KEGG: ace:Acel_1988 peptidase S1 and S6, chymotrypsin/Hap.
  
   
 0.758
Afer_0557
Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; KEGG: fra:Francci3_0309 periplasmic sensor signal transduction histidine kinase.
 
  
 0.721
Afer_0558
Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; SMART: response regulator receiver; KEGG: kra:Krad_3036 two component transcriptional regulator.
  
  
 0.704
Afer_0560
PFAM: Enoyl-CoA hydratase/isomerase; KEGG: dge:Dgeo_0145 enoyl-CoA hydratase/isomerase; Belongs to the enoyl-CoA hydratase/isomerase family.
   
  0.679
Afer_1753
PFAM: Mov34/MPN/PAD-1 family protein; SMART: Mov34/MPN/PAD-1 family protein; KEGG: sth:STH1150 hypothetical protein.
   
  0.548
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
   
 0.504
Afer_1472
PFAM: carbohydrate kinase FGGY; KEGG: rsq:Rsph17025_1200 glycerol kinase.
   
 0.504
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
   
 
  0.487
Afer_0556
PFAM: protein of unknown function DUF1707; KEGG: sco:SCO5045 hypothetical protein.
       0.447
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.