STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Afer_0576PFAM: TrwC relaxase; KEGG: fal:FRAAL6333 putative conjugal transfer protein TraA. (669 aa)    
Predicted Functional Partners:
Afer_0002
KEGG: rxy:Rxyl_0002 DNA polymerase III, beta subunit; TIGRFAM: DNA polymerase III, beta subunit; PFAM: DNA polymerase III beta chain; SMART: DNA polymerase III beta chain.
 
 
 0.861
Afer_0604
KEGG: fra:Francci3_2361 hypothetical protein.
 
   
 0.783
Afer_1938
PFAM: SMC domain protein; KEGG: mab:MAB_1421 hypothetical protein.
   
 
 0.768
Afer_0205
SMART: AAA ATPase; KEGG: sco:SCO6878 ATP-binding protein.
 
   
 0.760
Afer_1937
PFAM: metallophosphoesterase; KEGG: mbo:Mb1308 hypothetical protein.
   
 
 0.743
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.735
Afer_0206
KEGG: fre:Franean1_1381 type IV secretory pathway VirD4 protein-like protein.
 
   
 0.686
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
 
 0.682
Afer_0577
KEGG: oih:OB1441 hypothetical protein.
 
     0.633
Afer_0575
PFAM: aminotransferase class-III; KEGG: ace:Acel_1287 hypothetical protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
       0.625
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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