Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
Afer_0757KEGG: sgr:SGR_5851 hypothetical protein. (259 aa)    
Predicted Functional Partners:
Afer_0756
PFAM: phosphoesterase PA-phosphatase related; SMART: phosphoesterase PA-phosphatase related; KEGG: fra:Francci3_3059 phosphoesterase, PA- phosphatase related.
       0.823
Afer_0758
PFAM: alpha/beta hydrolase fold; KEGG: predicted protein.
       0.788
Afer_0755
PFAM: NUDIX hydrolase; KEGG: stp:Strop_1261 NUDIX hydrolase.
       0.773
Afer_0038
PFAM: transcriptional regulator PadR family protein; KEGG: fra:Francci3_4528 PadR family transcriptional regulator.
  
     0.681
Afer_1448
KEGG: fre:Franean1_0153 major facilitator transporter.
  
     0.655
pafA
Protein of unknown function DUF245 domain protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine.
 
   
 0.650
Afer_0754
PFAM: DSBA oxidoreductase; KEGG: fal:FRAAL2315 hypothetical protein.
       0.605
Afer_0908
PFAM: protein of unknown function DUF245 domain protein; protein of unknown function DUF275 domain protein; KEGG: fra:Francci3_2629 hypothetical protein.
 
   
 0.596
Afer_0759
PFAM: SNARE associated Golgi protein; KEGG: ank:AnaeK_1303 SNARE associated Golgi protein.
       0.570
arc
AAA ATPase central domain protein; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
 
     0.494
Your Current Organism:
Acidimicrobium ferrooxidans
NCBI taxonomy Id: 525909
Other names: A. ferrooxidans DSM 10331, Acidimicrobium ferrooxidans DSM 10331, Acidimicrobium ferrooxidans ICP, Acidimicrobium ferrooxidans str. DSM 10331, Acidimicrobium ferrooxidans strain DSM 10331
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